Prognostic Value of Longitudinal Strain After Primary Reperfusion Therapy in Patients with Anterior-wall Acute Myocardial Infarction

Yong Hyun Park, Soo Jin Kang, Jae Kwan Song, Eun Young Lee, Jong Min Song, Duk Hyun Kang, Young Hak Kim, Cheol Whan Lee, Myeong Ki Hong, Jae Joong Kim, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Objectives: We sought to test whether longitudinal strain (LS) can be a useful predictor of left ventricular (LV) remodeling after reperfusion therapy in acute myocardial infarction. Background: Predicting LV remodeling based on quantification of regional contractility remains an elusive goal of echocardiography. Methods: In 50 patients with anterior-wall acute myocardial infarction, the peak systolic velocity and LS were measured by Doppler tissue imaging (LSDTI) and speckle tracking imaging (LS2D) at 7 LV segments of left anterior descending coronary artery territory after primary reperfusion therapy. LV remodeling was defined as an increase in LV end-diastolic volume of greater than or equal to 15% at follow-up echocardiography. Results: A total of 22 patients showed LV remodeling, who had significantly lower baseline ejection fraction, LSDTI, and LS2D, and higher wall-motion score index and peak creatine kinase-MB with shorter deceleration time of early diastolic mitral inflow than those without LV remodeling. LS2D (odds ratio [OR] = 1.307, 95% confidence interval [CI] = 1.082-1.579, P = .005) and LSDTI (OR = 1.430, 95% CI = 1.152-1.776, P = .001) were independent predictors of LV remodeling. During clinical follow-up of 18.3 ± 9.0 months, death or congestive heart failure developed in 11 patients (22%); LS2D (OR = 1.455, 95% CI = 1.142-1.852, P = .002) and LSDTI (OR = 1.436, 95% CI = 1.093-1.888, P = .009) were independent predictors. Conclusions: LS immediately after primary reperfusion therapy is an excellent predictor of LV remodeling and adverse events in patients with anterior-wall acute myocardial infarction.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume21
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

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Anterior Wall Myocardial Infarction
Ventricular Remodeling
Reperfusion
Odds Ratio
Confidence Intervals
Therapeutics
Echocardiography
MB Form Creatine Kinase
Deceleration
Stroke Volume
Coronary Vessels
Heart Failure
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Park, Yong Hyun ; Kang, Soo Jin ; Song, Jae Kwan ; Lee, Eun Young ; Song, Jong Min ; Kang, Duk Hyun ; Kim, Young Hak ; Lee, Cheol Whan ; Hong, Myeong Ki ; Kim, Jae Joong ; Park, Seong Wook ; Park, Seung Jung. / Prognostic Value of Longitudinal Strain After Primary Reperfusion Therapy in Patients with Anterior-wall Acute Myocardial Infarction. In: Journal of the American Society of Echocardiography. 2008 ; Vol. 21, No. 3. pp. 262-267.
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title = "Prognostic Value of Longitudinal Strain After Primary Reperfusion Therapy in Patients with Anterior-wall Acute Myocardial Infarction",
abstract = "Objectives: We sought to test whether longitudinal strain (LS) can be a useful predictor of left ventricular (LV) remodeling after reperfusion therapy in acute myocardial infarction. Background: Predicting LV remodeling based on quantification of regional contractility remains an elusive goal of echocardiography. Methods: In 50 patients with anterior-wall acute myocardial infarction, the peak systolic velocity and LS were measured by Doppler tissue imaging (LSDTI) and speckle tracking imaging (LS2D) at 7 LV segments of left anterior descending coronary artery territory after primary reperfusion therapy. LV remodeling was defined as an increase in LV end-diastolic volume of greater than or equal to 15{\%} at follow-up echocardiography. Results: A total of 22 patients showed LV remodeling, who had significantly lower baseline ejection fraction, LSDTI, and LS2D, and higher wall-motion score index and peak creatine kinase-MB with shorter deceleration time of early diastolic mitral inflow than those without LV remodeling. LS2D (odds ratio [OR] = 1.307, 95{\%} confidence interval [CI] = 1.082-1.579, P = .005) and LSDTI (OR = 1.430, 95{\%} CI = 1.152-1.776, P = .001) were independent predictors of LV remodeling. During clinical follow-up of 18.3 ± 9.0 months, death or congestive heart failure developed in 11 patients (22{\%}); LS2D (OR = 1.455, 95{\%} CI = 1.142-1.852, P = .002) and LSDTI (OR = 1.436, 95{\%} CI = 1.093-1.888, P = .009) were independent predictors. Conclusions: LS immediately after primary reperfusion therapy is an excellent predictor of LV remodeling and adverse events in patients with anterior-wall acute myocardial infarction.",
author = "Park, {Yong Hyun} and Kang, {Soo Jin} and Song, {Jae Kwan} and Lee, {Eun Young} and Song, {Jong Min} and Kang, {Duk Hyun} and Kim, {Young Hak} and Lee, {Cheol Whan} and Hong, {Myeong Ki} and Kim, {Jae Joong} and Park, {Seong Wook} and Park, {Seung Jung}",
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Prognostic Value of Longitudinal Strain After Primary Reperfusion Therapy in Patients with Anterior-wall Acute Myocardial Infarction. / Park, Yong Hyun; Kang, Soo Jin; Song, Jae Kwan; Lee, Eun Young; Song, Jong Min; Kang, Duk Hyun; Kim, Young Hak; Lee, Cheol Whan; Hong, Myeong Ki; Kim, Jae Joong; Park, Seong Wook; Park, Seung Jung.

In: Journal of the American Society of Echocardiography, Vol. 21, No. 3, 01.03.2008, p. 262-267.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic Value of Longitudinal Strain After Primary Reperfusion Therapy in Patients with Anterior-wall Acute Myocardial Infarction

AU - Park, Yong Hyun

AU - Kang, Soo Jin

AU - Song, Jae Kwan

AU - Lee, Eun Young

AU - Song, Jong Min

AU - Kang, Duk Hyun

AU - Kim, Young Hak

AU - Lee, Cheol Whan

AU - Hong, Myeong Ki

AU - Kim, Jae Joong

AU - Park, Seong Wook

AU - Park, Seung Jung

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Objectives: We sought to test whether longitudinal strain (LS) can be a useful predictor of left ventricular (LV) remodeling after reperfusion therapy in acute myocardial infarction. Background: Predicting LV remodeling based on quantification of regional contractility remains an elusive goal of echocardiography. Methods: In 50 patients with anterior-wall acute myocardial infarction, the peak systolic velocity and LS were measured by Doppler tissue imaging (LSDTI) and speckle tracking imaging (LS2D) at 7 LV segments of left anterior descending coronary artery territory after primary reperfusion therapy. LV remodeling was defined as an increase in LV end-diastolic volume of greater than or equal to 15% at follow-up echocardiography. Results: A total of 22 patients showed LV remodeling, who had significantly lower baseline ejection fraction, LSDTI, and LS2D, and higher wall-motion score index and peak creatine kinase-MB with shorter deceleration time of early diastolic mitral inflow than those without LV remodeling. LS2D (odds ratio [OR] = 1.307, 95% confidence interval [CI] = 1.082-1.579, P = .005) and LSDTI (OR = 1.430, 95% CI = 1.152-1.776, P = .001) were independent predictors of LV remodeling. During clinical follow-up of 18.3 ± 9.0 months, death or congestive heart failure developed in 11 patients (22%); LS2D (OR = 1.455, 95% CI = 1.142-1.852, P = .002) and LSDTI (OR = 1.436, 95% CI = 1.093-1.888, P = .009) were independent predictors. Conclusions: LS immediately after primary reperfusion therapy is an excellent predictor of LV remodeling and adverse events in patients with anterior-wall acute myocardial infarction.

AB - Objectives: We sought to test whether longitudinal strain (LS) can be a useful predictor of left ventricular (LV) remodeling after reperfusion therapy in acute myocardial infarction. Background: Predicting LV remodeling based on quantification of regional contractility remains an elusive goal of echocardiography. Methods: In 50 patients with anterior-wall acute myocardial infarction, the peak systolic velocity and LS were measured by Doppler tissue imaging (LSDTI) and speckle tracking imaging (LS2D) at 7 LV segments of left anterior descending coronary artery territory after primary reperfusion therapy. LV remodeling was defined as an increase in LV end-diastolic volume of greater than or equal to 15% at follow-up echocardiography. Results: A total of 22 patients showed LV remodeling, who had significantly lower baseline ejection fraction, LSDTI, and LS2D, and higher wall-motion score index and peak creatine kinase-MB with shorter deceleration time of early diastolic mitral inflow than those without LV remodeling. LS2D (odds ratio [OR] = 1.307, 95% confidence interval [CI] = 1.082-1.579, P = .005) and LSDTI (OR = 1.430, 95% CI = 1.152-1.776, P = .001) were independent predictors of LV remodeling. During clinical follow-up of 18.3 ± 9.0 months, death or congestive heart failure developed in 11 patients (22%); LS2D (OR = 1.455, 95% CI = 1.142-1.852, P = .002) and LSDTI (OR = 1.436, 95% CI = 1.093-1.888, P = .009) were independent predictors. Conclusions: LS immediately after primary reperfusion therapy is an excellent predictor of LV remodeling and adverse events in patients with anterior-wall acute myocardial infarction.

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