Prognostic value of nuclear DNA quantification and cyclin A expression in epithelial ovarian carcinoma

Bo Sung Yoon, Young Tae Kim, Sunghoon Kim, Chong Seung Lee, Jae Wook Kim, Jae Hoon Kim, Sang Wun Kim, Nam Hoon Cho

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To investigate the correlation of DNA ploidy, S-phase fraction (SPF) and the expression of cyclin A to the clinical prognostic factors in patients with epithelial ovarian cancer. Study design: A prospective analysis was performed on 46 ovarian tumor patients. The DNA ploidy and SPF were determined by flow cytometry and the expression of cyclin A was measured by immunohistochemical staining. Results: Compared with benign and borderline tumors, the malignant tumors expressed higher levels of cyclin A (P = 0.007), more aneuploid cells (P = 0.018) and higher SPF (P = 0.015). With regard to DNA ploidy and the clinical prognostic factors, aneuploid cells increased with tumor grade (P = 0.011), the disease stage (P = 0.009) and residual volume (P = 0.001). When residual tumor was more than 2 cm, the expression of cyclin A was increased (P = 0.043). Three-year survival was low for patients with tumors expressing cyclin A in over 10% of cells (P = 0.003). Conclusions: The data suggest that the assessment of the DNA ploidy, SPF and the expression of cyclin A may provide important information for predicting the prognosis of epithelial ovarian cancer.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume136
Issue number1
DOIs
Publication statusPublished - 2008 Jan

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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