Objective: To investigate the correlation of DNA ploidy, S-phase fraction (SPF) and the expression of cyclin A to the clinical prognostic factors in patients with epithelial ovarian cancer. Study design: A prospective analysis was performed on 46 ovarian tumor patients. The DNA ploidy and SPF were determined by flow cytometry and the expression of cyclin A was measured by immunohistochemical staining. Results: Compared with benign and borderline tumors, the malignant tumors expressed higher levels of cyclin A (P = 0.007), more aneuploid cells (P = 0.018) and higher SPF (P = 0.015). With regard to DNA ploidy and the clinical prognostic factors, aneuploid cells increased with tumor grade (P = 0.011), the disease stage (P = 0.009) and residual volume (P = 0.001). When residual tumor was more than 2 cm, the expression of cyclin A was increased (P = 0.043). Three-year survival was low for patients with tumors expressing cyclin A in over 10% of cells (P = 0.003). Conclusions: The data suggest that the assessment of the DNA ploidy, SPF and the expression of cyclin A may provide important information for predicting the prognosis of epithelial ovarian cancer.
|Number of pages||6|
|Journal||European Journal of Obstetrics and Gynecology and Reproductive Biology|
|Publication status||Published - 2008 Jan|
Bibliographical noteFunding Information:
This study was supported by Brain Korea 21 Project for Medical Science, Yonsei University.
All Science Journal Classification (ASJC) codes
- Reproductive Medicine
- Obstetrics and Gynaecology