Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients: A single-institution experience

Chi Young Kim, Ji Eun Park, Ah Young Leem, Joo Han Song, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Joon Chang, Jin Gu Lee, Hyo Chae Paik, Moo Suk Park

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Currently, lung transplantation (LTX) is considered to be a curative treatment option in patients with end-stage lung disease. Although pulmonary hypertension (PH), confirmed by cardiac catheterization, is a prognostic factor in patients undergoing LTX, the prognostic value of PH in Asian lung transplant recipients remains uncertain. In this study, we aimed to determine whether PH before LTX may serve as a prognostic factor for survival in Asian patients. Methods: The medical records of 50 patients [male, 27; female, 23; mean age, 51.0 (41.0-60.0) years], who received preoperative right heart catheterization (RHC) and echocardiography before single or double LTX at Severance Hospital between January 2010 and December 2014, were reviewed. The relationship between 1-year survival after LTX and PH [mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest] was evaluated. Results: The mean right ventricular systolic pressure and mPAP were 48.5 (22.8) and 30.0 (24.0-40.0) mmHg. Of the 50 patients, 17 (34.0%) died within a year after LTX. The 1-year survival rate among patients with mPAP ≥25 mmHg (58.8%) was lower than the survival rate among patients with mPAP < 25 mmHg (87.5%). Pre-transplantation mPAP of ≥25 mmHg was associated with post-transplantation survival [hazard ratio (HR), 4.832; 95% confidence interval (CI), 1.080-21.608, P=0.039]. The presence of preoperative PH was also associated with an increased risk of postoperative complications. Conclusions: Confirmation of PH via preoperative cardiac catheterization was associated with the prognosis of the patient after LTX. Clinicians should consider the necessity for early transplantation surgery before the mPAP reaches ≥25 mmHg.

Original languageEnglish
Pages (from-to)1578-1587
Number of pages10
JournalJournal of Thoracic Disease
Volume10
Issue number3
DOIs
Publication statusPublished - 2018 Mar 1

Fingerprint

Arterial Pressure
Pulmonary Hypertension
Transplants
Lung
Cardiac Catheterization
Transplantation
Survival
Survival Rate
Lung Transplantation
Transplant Recipients
Ventricular Pressure
Lung Diseases
Medical Records
Echocardiography
Confidence Intervals
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Kim, Chi Young ; Park, Ji Eun ; Leem, Ah Young ; Song, Joo Han ; Kim, Song Yee ; Chung, Kyung Soo ; Kim, Eun Young ; Jung, Ji Ye ; Kang, Young Ae ; Kim, Young Sam ; Chang, Joon ; Lee, Jin Gu ; Paik, Hyo Chae ; Park, Moo Suk. / Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients : A single-institution experience. In: Journal of Thoracic Disease. 2018 ; Vol. 10, No. 3. pp. 1578-1587.
@article{3b0c7d88d5b145578e7e73dcb7504b36,
title = "Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients: A single-institution experience",
abstract = "Background: Currently, lung transplantation (LTX) is considered to be a curative treatment option in patients with end-stage lung disease. Although pulmonary hypertension (PH), confirmed by cardiac catheterization, is a prognostic factor in patients undergoing LTX, the prognostic value of PH in Asian lung transplant recipients remains uncertain. In this study, we aimed to determine whether PH before LTX may serve as a prognostic factor for survival in Asian patients. Methods: The medical records of 50 patients [male, 27; female, 23; mean age, 51.0 (41.0-60.0) years], who received preoperative right heart catheterization (RHC) and echocardiography before single or double LTX at Severance Hospital between January 2010 and December 2014, were reviewed. The relationship between 1-year survival after LTX and PH [mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest] was evaluated. Results: The mean right ventricular systolic pressure and mPAP were 48.5 (22.8) and 30.0 (24.0-40.0) mmHg. Of the 50 patients, 17 (34.0{\%}) died within a year after LTX. The 1-year survival rate among patients with mPAP ≥25 mmHg (58.8{\%}) was lower than the survival rate among patients with mPAP < 25 mmHg (87.5{\%}). Pre-transplantation mPAP of ≥25 mmHg was associated with post-transplantation survival [hazard ratio (HR), 4.832; 95{\%} confidence interval (CI), 1.080-21.608, P=0.039]. The presence of preoperative PH was also associated with an increased risk of postoperative complications. Conclusions: Confirmation of PH via preoperative cardiac catheterization was associated with the prognosis of the patient after LTX. Clinicians should consider the necessity for early transplantation surgery before the mPAP reaches ≥25 mmHg.",
author = "Kim, {Chi Young} and Park, {Ji Eun} and Leem, {Ah Young} and Song, {Joo Han} and Kim, {Song Yee} and Chung, {Kyung Soo} and Kim, {Eun Young} and Jung, {Ji Ye} and Kang, {Young Ae} and Kim, {Young Sam} and Joon Chang and Lee, {Jin Gu} and Paik, {Hyo Chae} and Park, {Moo Suk}",
year = "2018",
month = "3",
day = "1",
doi = "10.21037/jtd.2018.03.46",
language = "English",
volume = "10",
pages = "1578--1587",
journal = "Journal of Thoracic Disease",
issn = "2072-1439",
publisher = "Pioneer Bioscience Publishing Company (PBPC)",
number = "3",

}

Kim, CY, Park, JE, Leem, AY, Song, JH, Kim, SY, Chung, KS, Kim, EY, Jung, JY, Kang, YA, Kim, YS, Chang, J, Lee, JG, Paik, HC & Park, MS 2018, 'Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients: A single-institution experience', Journal of Thoracic Disease, vol. 10, no. 3, pp. 1578-1587. https://doi.org/10.21037/jtd.2018.03.46

Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients : A single-institution experience. / Kim, Chi Young; Park, Ji Eun; Leem, Ah Young; Song, Joo Han; Kim, Song Yee; Chung, Kyung Soo; Kim, Eun Young; Jung, Ji Ye; Kang, Young Ae; Kim, Young Sam; Chang, Joon; Lee, Jin Gu; Paik, Hyo Chae; Park, Moo Suk.

In: Journal of Thoracic Disease, Vol. 10, No. 3, 01.03.2018, p. 1578-1587.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic value of pre-transplant mean pulmonary arterial pressure in lung transplant recipients

T2 - A single-institution experience

AU - Kim, Chi Young

AU - Park, Ji Eun

AU - Leem, Ah Young

AU - Song, Joo Han

AU - Kim, Song Yee

AU - Chung, Kyung Soo

AU - Kim, Eun Young

AU - Jung, Ji Ye

AU - Kang, Young Ae

AU - Kim, Young Sam

AU - Chang, Joon

AU - Lee, Jin Gu

AU - Paik, Hyo Chae

AU - Park, Moo Suk

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Currently, lung transplantation (LTX) is considered to be a curative treatment option in patients with end-stage lung disease. Although pulmonary hypertension (PH), confirmed by cardiac catheterization, is a prognostic factor in patients undergoing LTX, the prognostic value of PH in Asian lung transplant recipients remains uncertain. In this study, we aimed to determine whether PH before LTX may serve as a prognostic factor for survival in Asian patients. Methods: The medical records of 50 patients [male, 27; female, 23; mean age, 51.0 (41.0-60.0) years], who received preoperative right heart catheterization (RHC) and echocardiography before single or double LTX at Severance Hospital between January 2010 and December 2014, were reviewed. The relationship between 1-year survival after LTX and PH [mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest] was evaluated. Results: The mean right ventricular systolic pressure and mPAP were 48.5 (22.8) and 30.0 (24.0-40.0) mmHg. Of the 50 patients, 17 (34.0%) died within a year after LTX. The 1-year survival rate among patients with mPAP ≥25 mmHg (58.8%) was lower than the survival rate among patients with mPAP < 25 mmHg (87.5%). Pre-transplantation mPAP of ≥25 mmHg was associated with post-transplantation survival [hazard ratio (HR), 4.832; 95% confidence interval (CI), 1.080-21.608, P=0.039]. The presence of preoperative PH was also associated with an increased risk of postoperative complications. Conclusions: Confirmation of PH via preoperative cardiac catheterization was associated with the prognosis of the patient after LTX. Clinicians should consider the necessity for early transplantation surgery before the mPAP reaches ≥25 mmHg.

AB - Background: Currently, lung transplantation (LTX) is considered to be a curative treatment option in patients with end-stage lung disease. Although pulmonary hypertension (PH), confirmed by cardiac catheterization, is a prognostic factor in patients undergoing LTX, the prognostic value of PH in Asian lung transplant recipients remains uncertain. In this study, we aimed to determine whether PH before LTX may serve as a prognostic factor for survival in Asian patients. Methods: The medical records of 50 patients [male, 27; female, 23; mean age, 51.0 (41.0-60.0) years], who received preoperative right heart catheterization (RHC) and echocardiography before single or double LTX at Severance Hospital between January 2010 and December 2014, were reviewed. The relationship between 1-year survival after LTX and PH [mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest] was evaluated. Results: The mean right ventricular systolic pressure and mPAP were 48.5 (22.8) and 30.0 (24.0-40.0) mmHg. Of the 50 patients, 17 (34.0%) died within a year after LTX. The 1-year survival rate among patients with mPAP ≥25 mmHg (58.8%) was lower than the survival rate among patients with mPAP < 25 mmHg (87.5%). Pre-transplantation mPAP of ≥25 mmHg was associated with post-transplantation survival [hazard ratio (HR), 4.832; 95% confidence interval (CI), 1.080-21.608, P=0.039]. The presence of preoperative PH was also associated with an increased risk of postoperative complications. Conclusions: Confirmation of PH via preoperative cardiac catheterization was associated with the prognosis of the patient after LTX. Clinicians should consider the necessity for early transplantation surgery before the mPAP reaches ≥25 mmHg.

UR - http://www.scopus.com/inward/record.url?scp=85045315635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045315635&partnerID=8YFLogxK

U2 - 10.21037/jtd.2018.03.46

DO - 10.21037/jtd.2018.03.46

M3 - Article

AN - SCOPUS:85045315635

VL - 10

SP - 1578

EP - 1587

JO - Journal of Thoracic Disease

JF - Journal of Thoracic Disease

SN - 2072-1439

IS - 3

ER -