Progression patterns of normal-tension glaucoma groups classified by hierarchical cluster analysis

Eun Woo Kim, Hyo Song Park, Wungrak Choi, Kwanghyun Lee, Sang Yeop Lee, Gong Je Seong, Chan Yun Kim, Hyoung Won Bae

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1 Citation (Scopus)


Objectives: To investigate differences in progression patterns of normal-tension glaucoma (NTG) patients in three clusters classified by hierarchical cluster analysis (HCA). Materials and methods: In a retrospective study, 200 eyes of NTG patients classified by HCA in 2015 who were followed up to the current date were evaluated. Peripapillary retinal nerve fibre layer (RNFL) thicknesses were measured by Cirrus HD-OCT and progression rate was calculated by trend analysis (Guided Progression Analysis [GPA]). VF progression rate was evaluated by linear regression analysis of mean deviation (MD). Progression patterns of three clusters were compared by histograms. Results: In total, 153 eyes of 153 patients were followed up. Mean observation period was 5 years. RNFL reduction rate was −0.83 μm/year in cluster 1, which showed early glaucomatous damage in previous reports; −0.45 μm/year in cluster 2, which showed moderate glaucomatous damage; and −0.36 μm/year in cluster 3, which showed young and myopic glaucomatous damage. The progression pattern of cluster 3 showed a double-peak distribution; RNFL reduction rate was 0.11 μm/year in the non-progressive group and −1.07 μm/year in the progressive group. Conclusion: The progression patterns were different among three NTG groups that were divided by HCA. In particular, the group of young and myopic eyes showed a mixture of two different patterns.

Original languageEnglish
Pages (from-to)536-543
Number of pages8
JournalEye (Basingstoke)
Issue number2
Publication statusPublished - 2021 Feb

Bibliographical note

Funding Information:
Funding This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. NRF-2019R1F1A1061795). The funding organisation played no role in study design or conduct.

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to The Royal College of Ophthalmologists.

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems


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