Progressive retinal nerve fibre layer thinning and choroidal microvasculature dropout at the location of disc haemorrhage in glaucoma

Chung Young Kim, Eun Ji Lee, Ji Ah Kim, Hyunjoong Kim, Tae Woo Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background/Aims To investigate whether parapapillary choroidal microvasculature dropout (MvD) is associated with progressive retinal nerve fibre layer (RNFL) thinning in eyes with primary open-angle glaucoma (POAG) and disc haemorrhage (DH). Methods Parapapillary microvasculature was evaluated by swept-source optical coherence tomography (OCT) angiography (OCTA) in 50 eyes with POAG and DH, 1 year before, at the time of and 1 year after the detection of DH. MvD was defined as an area in the parapapillary deep layer of focal sectoral dropout with no visible microvascular network. Progressive changes in OCT RNFL thickness were compared in groups of eyes with and without MvD. Results Cumulative prevalence of MvD was 76.0% (38 eyes) at 1 year after detection of DH. All MvDs were detected in the same sectoral locations as DH. In eyes with MvD, global RNFL thickness and sectoral RNFL thickness at the location of DH were significantly reduced, both from 1 year before to the time of DH detection (both p<0.001) and from DH detection to 1 year later (both p<0.001). In eyes without MvD, however, the reductions in global (p=0.011) and sectoral (p=0.007) RNFL thickness were significant only from DH detection to 1 year later. Conclusion In eyes with POAG, RNFL thinning was spatially consistent and progressive at the location of MvD accompanied by subsequent DH and continued to progress after the occurrence of DH. When DH was not accompanied by MvD, progressive RNFL thinning was more likely to occur after the detection of DH.

Original languageEnglish
Pages (from-to)674-680
Number of pages7
JournalBritish Journal of Ophthalmology
Issue number5
Publication statusPublished - 2021 May 1

Bibliographical note

Funding Information:
Funding None of the authors have proprietary or commercial interest in any of the materials discussed in this article. This work was supported by the Seoul National University Bundang Hospital Research Fund (no. 02-2016-023) and by Basic Science Research programme through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (No. 2016R1D1A1B02011696). The funders had no role in the design or conduct of this research.

Publisher Copyright:
© 2021 BMJ Publishing Group. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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