Proinflammatory Effects of Calprotectin in Graves’ Orbitopathy

Ji Won Kim, Jae Sang Ko, Jin Joo Kim, Jin Sook Yoon

Research output: Contribution to journalArticle

Abstract

Purpose: Early detection and control of inflammation are important to manage Graves’ orbitopathy (GO). We investigated the effects of calprotectin (S100A8/A9) on orbital fibroblast inflammation and GO pathogenesis. Methods: We measured serum calprotectin, S100A8 and S100A9 mRNA expression in orbital fat/connective tissue from GO patients and healthy controls, and proinflammatory cytokines in primary cultured orbital fibroblasts. Results: The serum levels of S100A8/A9 and the expression of S100A8/A9 mRNA in orbital tissue were higher in the GO patients than in the healthy controls. The serum calprotectin levels positively correlated with the clinical activity score and serum thyroid-stimulating immunoglobulin levels. In cultured GO orbital fibroblasts, S100A8/A9 increased the expression of interleukin (IL)-6, IL-8, and monocyte chemotactic protein-1, as well as the phosphorylation of extracellular signal-regulated kinase and nuclear factor-κB. Conclusion: We demonstrated the potential of calprotectin as a biomarker of GO severity and proinflammatory responses to S100A8/A9 in GO orbital fibroblasts.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalOcular Immunology and Inflammation
Volume28
Issue number1
DOIs
Publication statusPublished - 2020 Jan 2

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology

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