One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2-11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5′-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).
Bibliographical noteFunding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Plant Science
- Complementary and alternative medicine