Proliferation effects on hair growth of compounds isolated from the bark of Dalbergia oliveri

Seon Ju Park, Nguyen Xuan Nhiem, Bui Huu Tai, Hoang Le Tuan Anh, Seok Hyun Oh, Jong Hyuk Sung, Nanyoung Kim, Guijae Yoo, Jun Hyung Park, Hee Jae Kwak, Pham Thanh Loan, Seung Hyun Kim, Phan Van Kiem

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Abstract

One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2-11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5′-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).

Original languageEnglish
Pages (from-to)1729-1730
Number of pages2
JournalNatural product communications
Volume12
Issue number11
Publication statusPublished - 2017 Jan 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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    Park, S. J., Nhiem, N. X., Tai, B. H., Anh, H. L. T., Oh, S. H., Sung, J. H., Kim, N., Yoo, G., Park, J. H., Kwak, H. J., Loan, P. T., Kim, S. H., & Van Kiem, P. (2017). Proliferation effects on hair growth of compounds isolated from the bark of Dalbergia oliveri. Natural product communications, 12(11), 1729-1730.