Proliferation effects on hair growth of compounds isolated from the bark of Dalbergia oliveri

Seon Ju Park; Nguyen Xuan Nhiem; Bui Huu Tai; Hoang Le Tuan Anh; Seok Hyun Oh; Jong Hyuk Sung; Nanyoung Kim; Guijae Yoo; Jun Hyung Park; Hee Jae Kwak; Pham Thanh Loan; Seung Hyun Kim; Phan Van Kiem

doi:10.1177/1934578x1701201117

Proliferation effects on hair growth of compounds isolated from the bark of Dalbergia oliveri

Seon Ju Park, Nguyen Xuan Nhiem, Bui Huu Tai, Hoang Le Tuan Anh, Seok Hyun Oh, Jong Hyuk Sung, Nanyoung Kim, Guijae Yoo, Jun Hyung Park, Hee Jae Kwak, Pham Thanh Loan, Seung Hyun Kim, Phan Van Kiem

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2-11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5′-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).

Original language	English
Pages (from-to)	1729-1730
Number of pages	2
Journal	Natural product communications
Volume	12
Issue number	11
DOIs	https://doi.org/10.1177/1934578x1701201117
Publication status	Published - 2017 Nov

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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10.1177/1934578x1701201117

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title = "Proliferation effects on hair growth of compounds isolated from the bark of Dalbergia oliveri",

abstract = "One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2-11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5′-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).",

author = "Park, {Seon Ju} and Nhiem, {Nguyen Xuan} and Tai, {Bui Huu} and Anh, {Hoang Le Tuan} and Oh, {Seok Hyun} and Sung, {Jong Hyuk} and Nanyoung Kim and Guijae Yoo and Park, {Jun Hyung} and Kwak, {Hee Jae} and Loan, {Pham Thanh} and Kim, {Seung Hyun} and {Van Kiem}, Phan",

note = "Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.",

year = "2017",

month = nov,

doi = "10.1177/1934578x1701201117",

language = "English",

volume = "12",

pages = "1729--1730",

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AU - Park, Seon Ju

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Anh, Hoang Le Tuan

AU - Oh, Seok Hyun

AU - Sung, Jong Hyuk

AU - Kim, Nanyoung

AU - Yoo, Guijae

AU - Park, Jun Hyung

AU - Kwak, Hee Jae

AU - Loan, Pham Thanh

AU - Kim, Seung Hyun

AU - Van Kiem, Phan

N1 - Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.

PY - 2017/11

Y1 - 2017/11

N2 - One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2-11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5′-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).

AB - One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2-11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5′-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).

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Proliferation effects on hair growth of compounds isolated from the bark of Dalbergia oliveri

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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