Prolonged atrial refractoriness predicts the onset of atrial fibrillation: A 12-year follow-up study

Jung Myung Lee, Hancheol Lee, Ajit H. Janardhan, Junbeom Park, Boyoung Joung, huinam pak, Moon Hyoung Lee, Sung Soon Kim, Hye Jin Hwang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. Objectives We investigated whether atrial effective refractory period (AERP) was associated with AF occurrence in a relatively healthy population. Methods A total of 1308 patients with no overt structural heart diseases and no evidence of congestive heart failure who underwent electrophysiology studies for paroxysmal supraventricular tachycardia from January 1986 to January 2011 were included in the study (626 male, mean age 44 ± 16 years). Results AERP increased with increasing age. Over a mean follow-up of 12 years, 51 of 1308 subjects (3.9%) developed AF. In univariate analysis, baseline AERP ≥280 ms (hazard ratio [HR] 2.54, 95% confidence interval [CI] 1.27–5.07, P = .008) was strongly associated with new-onset AF. In multivariate Cox regression analysis, age (adjusted HR 1.40 per 10 years, 95% CI 1.15–1.70, P = .001) and AERP ≥280 ms (adjusted HR 2.08, 95% CI 1.03–4.21, P = .041) were associated with new-onset AF. Kaplan-Meier AF-free survival curves demonstrated that subjects with an AERP of ≥280 ms had significantly lower AF-free survival compared those with AERP of <280 ms. Conclusions AERP increases with age and AERP of ≥280 ms was predictive of patients at significantly increased future risk of developing AF.

Original languageEnglish
Pages (from-to)1575-1580
Number of pages6
JournalHeart Rhythm
Volume13
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1

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compound A 12
Atrial Fibrillation
Confidence Intervals
Paroxysmal Tachycardia
Supraventricular Tachycardia
Survival
Electrophysiology
Heart Diseases
Heart Failure
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Lee, Jung Myung ; Lee, Hancheol ; Janardhan, Ajit H. ; Park, Junbeom ; Joung, Boyoung ; pak, huinam ; Lee, Moon Hyoung ; Kim, Sung Soon ; Hwang, Hye Jin. / Prolonged atrial refractoriness predicts the onset of atrial fibrillation : A 12-year follow-up study. In: Heart Rhythm. 2016 ; Vol. 13, No. 8. pp. 1575-1580.
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title = "Prolonged atrial refractoriness predicts the onset of atrial fibrillation: A 12-year follow-up study",
abstract = "Background Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. Objectives We investigated whether atrial effective refractory period (AERP) was associated with AF occurrence in a relatively healthy population. Methods A total of 1308 patients with no overt structural heart diseases and no evidence of congestive heart failure who underwent electrophysiology studies for paroxysmal supraventricular tachycardia from January 1986 to January 2011 were included in the study (626 male, mean age 44 ± 16 years). Results AERP increased with increasing age. Over a mean follow-up of 12 years, 51 of 1308 subjects (3.9{\%}) developed AF. In univariate analysis, baseline AERP ≥280 ms (hazard ratio [HR] 2.54, 95{\%} confidence interval [CI] 1.27–5.07, P = .008) was strongly associated with new-onset AF. In multivariate Cox regression analysis, age (adjusted HR 1.40 per 10 years, 95{\%} CI 1.15–1.70, P = .001) and AERP ≥280 ms (adjusted HR 2.08, 95{\%} CI 1.03–4.21, P = .041) were associated with new-onset AF. Kaplan-Meier AF-free survival curves demonstrated that subjects with an AERP of ≥280 ms had significantly lower AF-free survival compared those with AERP of <280 ms. Conclusions AERP increases with age and AERP of ≥280 ms was predictive of patients at significantly increased future risk of developing AF.",
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Prolonged atrial refractoriness predicts the onset of atrial fibrillation : A 12-year follow-up study. / Lee, Jung Myung; Lee, Hancheol; Janardhan, Ajit H.; Park, Junbeom; Joung, Boyoung; pak, huinam; Lee, Moon Hyoung; Kim, Sung Soon; Hwang, Hye Jin.

In: Heart Rhythm, Vol. 13, No. 8, 01.08.2016, p. 1575-1580.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prolonged atrial refractoriness predicts the onset of atrial fibrillation

T2 - A 12-year follow-up study

AU - Lee, Jung Myung

AU - Lee, Hancheol

AU - Janardhan, Ajit H.

AU - Park, Junbeom

AU - Joung, Boyoung

AU - pak, huinam

AU - Lee, Moon Hyoung

AU - Kim, Sung Soon

AU - Hwang, Hye Jin

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. Objectives We investigated whether atrial effective refractory period (AERP) was associated with AF occurrence in a relatively healthy population. Methods A total of 1308 patients with no overt structural heart diseases and no evidence of congestive heart failure who underwent electrophysiology studies for paroxysmal supraventricular tachycardia from January 1986 to January 2011 were included in the study (626 male, mean age 44 ± 16 years). Results AERP increased with increasing age. Over a mean follow-up of 12 years, 51 of 1308 subjects (3.9%) developed AF. In univariate analysis, baseline AERP ≥280 ms (hazard ratio [HR] 2.54, 95% confidence interval [CI] 1.27–5.07, P = .008) was strongly associated with new-onset AF. In multivariate Cox regression analysis, age (adjusted HR 1.40 per 10 years, 95% CI 1.15–1.70, P = .001) and AERP ≥280 ms (adjusted HR 2.08, 95% CI 1.03–4.21, P = .041) were associated with new-onset AF. Kaplan-Meier AF-free survival curves demonstrated that subjects with an AERP of ≥280 ms had significantly lower AF-free survival compared those with AERP of <280 ms. Conclusions AERP increases with age and AERP of ≥280 ms was predictive of patients at significantly increased future risk of developing AF.

AB - Background Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. Objectives We investigated whether atrial effective refractory period (AERP) was associated with AF occurrence in a relatively healthy population. Methods A total of 1308 patients with no overt structural heart diseases and no evidence of congestive heart failure who underwent electrophysiology studies for paroxysmal supraventricular tachycardia from January 1986 to January 2011 were included in the study (626 male, mean age 44 ± 16 years). Results AERP increased with increasing age. Over a mean follow-up of 12 years, 51 of 1308 subjects (3.9%) developed AF. In univariate analysis, baseline AERP ≥280 ms (hazard ratio [HR] 2.54, 95% confidence interval [CI] 1.27–5.07, P = .008) was strongly associated with new-onset AF. In multivariate Cox regression analysis, age (adjusted HR 1.40 per 10 years, 95% CI 1.15–1.70, P = .001) and AERP ≥280 ms (adjusted HR 2.08, 95% CI 1.03–4.21, P = .041) were associated with new-onset AF. Kaplan-Meier AF-free survival curves demonstrated that subjects with an AERP of ≥280 ms had significantly lower AF-free survival compared those with AERP of <280 ms. Conclusions AERP increases with age and AERP of ≥280 ms was predictive of patients at significantly increased future risk of developing AF.

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