Prominent Langerhans' cell migration in the arthropod bite reactions simulating Langerhans' cell histiocytosis

SeHoon Kim, Dong Hyun Kim, Kwang Gil Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Epidermal Langerhans' cells (LCs) play pivotal roles in cutaneous immune responses. An encounter with antigens or other stimuli causes the mobilization and migration of LCs. Therefore, some dermatoses, which originated from antigenic stimuli or trauma, can show LC migration. Recently, we experienced several cases of anthropod bites that showed marked inflammatory infiltrates with eosinophils and CD1a-positive LCs. It was difficult to differentiate these cases from Langerhans' cell histiocytosis (LCH). Methods: The degree and pattern of LC infiltration in the skin of arthropod bite reaction was evaluated. The characteristics of CD1a immunohistochemical expression in the arthropod bite reactions were compared with those of LCH. Results: A few arthropod bite cases (approximately 36%) showed extensive CD1a-positive LCs in the dermis, especially in the perivascular area. In addition, the CD1a expression patterns of LCs in the arthropod bite reactions were dendritic, whereas that of tumor cells in LCH were distinctly membranous and cytoplasmic. Conclusion: Some arthropod bite reactions can show marked CD1a-positive LCs in the dermis, especially in the perivascular area. The dendritic CD1a immunohistochemical staining pattern in arthropod bite reactions is useful in helping to differentiate from LCH.

Original languageEnglish
Pages (from-to)899-902
Number of pages4
JournalJournal of Cutaneous Pathology
Volume34
Issue number12
DOIs
Publication statusPublished - 2007 Dec 1

Fingerprint

Langerhans Cell Histiocytosis
Langerhans Cells
Arthropods
Bites and Stings
Cell Movement
Dermis
Skin
Skin Diseases
Eosinophils
Staining and Labeling
Antigens
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

@article{2576a5ff511a49f4887014d2fa6057dc,
title = "Prominent Langerhans' cell migration in the arthropod bite reactions simulating Langerhans' cell histiocytosis",
abstract = "Background: Epidermal Langerhans' cells (LCs) play pivotal roles in cutaneous immune responses. An encounter with antigens or other stimuli causes the mobilization and migration of LCs. Therefore, some dermatoses, which originated from antigenic stimuli or trauma, can show LC migration. Recently, we experienced several cases of anthropod bites that showed marked inflammatory infiltrates with eosinophils and CD1a-positive LCs. It was difficult to differentiate these cases from Langerhans' cell histiocytosis (LCH). Methods: The degree and pattern of LC infiltration in the skin of arthropod bite reaction was evaluated. The characteristics of CD1a immunohistochemical expression in the arthropod bite reactions were compared with those of LCH. Results: A few arthropod bite cases (approximately 36{\%}) showed extensive CD1a-positive LCs in the dermis, especially in the perivascular area. In addition, the CD1a expression patterns of LCs in the arthropod bite reactions were dendritic, whereas that of tumor cells in LCH were distinctly membranous and cytoplasmic. Conclusion: Some arthropod bite reactions can show marked CD1a-positive LCs in the dermis, especially in the perivascular area. The dendritic CD1a immunohistochemical staining pattern in arthropod bite reactions is useful in helping to differentiate from LCH.",
author = "SeHoon Kim and Kim, {Dong Hyun} and Lee, {Kwang Gil}",
year = "2007",
month = "12",
day = "1",
doi = "10.1111/j.1600-0560.2007.00751.x",
language = "English",
volume = "34",
pages = "899--902",
journal = "Journal of Cutaneous Pathology",
issn = "0303-6987",
publisher = "Wiley-Blackwell",
number = "12",

}

Prominent Langerhans' cell migration in the arthropod bite reactions simulating Langerhans' cell histiocytosis. / Kim, SeHoon; Kim, Dong Hyun; Lee, Kwang Gil.

In: Journal of Cutaneous Pathology, Vol. 34, No. 12, 01.12.2007, p. 899-902.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prominent Langerhans' cell migration in the arthropod bite reactions simulating Langerhans' cell histiocytosis

AU - Kim, SeHoon

AU - Kim, Dong Hyun

AU - Lee, Kwang Gil

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Background: Epidermal Langerhans' cells (LCs) play pivotal roles in cutaneous immune responses. An encounter with antigens or other stimuli causes the mobilization and migration of LCs. Therefore, some dermatoses, which originated from antigenic stimuli or trauma, can show LC migration. Recently, we experienced several cases of anthropod bites that showed marked inflammatory infiltrates with eosinophils and CD1a-positive LCs. It was difficult to differentiate these cases from Langerhans' cell histiocytosis (LCH). Methods: The degree and pattern of LC infiltration in the skin of arthropod bite reaction was evaluated. The characteristics of CD1a immunohistochemical expression in the arthropod bite reactions were compared with those of LCH. Results: A few arthropod bite cases (approximately 36%) showed extensive CD1a-positive LCs in the dermis, especially in the perivascular area. In addition, the CD1a expression patterns of LCs in the arthropod bite reactions were dendritic, whereas that of tumor cells in LCH were distinctly membranous and cytoplasmic. Conclusion: Some arthropod bite reactions can show marked CD1a-positive LCs in the dermis, especially in the perivascular area. The dendritic CD1a immunohistochemical staining pattern in arthropod bite reactions is useful in helping to differentiate from LCH.

AB - Background: Epidermal Langerhans' cells (LCs) play pivotal roles in cutaneous immune responses. An encounter with antigens or other stimuli causes the mobilization and migration of LCs. Therefore, some dermatoses, which originated from antigenic stimuli or trauma, can show LC migration. Recently, we experienced several cases of anthropod bites that showed marked inflammatory infiltrates with eosinophils and CD1a-positive LCs. It was difficult to differentiate these cases from Langerhans' cell histiocytosis (LCH). Methods: The degree and pattern of LC infiltration in the skin of arthropod bite reaction was evaluated. The characteristics of CD1a immunohistochemical expression in the arthropod bite reactions were compared with those of LCH. Results: A few arthropod bite cases (approximately 36%) showed extensive CD1a-positive LCs in the dermis, especially in the perivascular area. In addition, the CD1a expression patterns of LCs in the arthropod bite reactions were dendritic, whereas that of tumor cells in LCH were distinctly membranous and cytoplasmic. Conclusion: Some arthropod bite reactions can show marked CD1a-positive LCs in the dermis, especially in the perivascular area. The dendritic CD1a immunohistochemical staining pattern in arthropod bite reactions is useful in helping to differentiate from LCH.

UR - http://www.scopus.com/inward/record.url?scp=36248975260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36248975260&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0560.2007.00751.x

DO - 10.1111/j.1600-0560.2007.00751.x

M3 - Article

VL - 34

SP - 899

EP - 902

JO - Journal of Cutaneous Pathology

JF - Journal of Cutaneous Pathology

SN - 0303-6987

IS - 12

ER -