Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia

Young Chul Yoo, Kyung Jong Yoo, Beom Jin Lim, Ji Hae Jun, Jae Kwang Shim, Young Lan Kwak

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Background: Hyperglycemia exacerbates renal ischemia-reperfusion (IR) injury via aggravated inflammatory response and excessive production of reactive oxygen species. This study aimed to investigate the ability of propofol, a known antioxidant, to protect kidneys against IR injury in hyperglycemic rats in comparison with normoglycemic rats. Methods: Sixty rats were randomly assigned to four groups: normoglycemia-etomidate, normoglycemia-propofol, hyperglycemia-etomidate, and hyperglycemia-propofol. Anesthesia was provided with propofol or etomidate depending on the group. Also, the rats received 1.2 g/kg dextrose or the same volume of normal saline depending on the group. Renal ischemia was induced for 25 min. The rats were killed, and samples were collected 65 min after starting intravenous anesthetics (sham) and 15 min and 24 h after reperfusion injury to compare the histologic degree of renal tubular damage and levels of inflammatory markers and enzymes related to reactive oxygen species. Results: Compared with etomidate, propofol significantly attenuated tubular damage after reperfusion in hyperglycemic rats. Also, tubular damage was greater under hyperglycemia compared with normoglycemia in the etomidate group, whereas it was similar in the propofol group. Propofol preserved superoxide dismutase level and attenuated the increase in levels of myeloperoxidase, interlukin-1β, and tumor necrosis factor-α after reperfusion compared with etomidate especially in hyperglycemic rats. Propofol also attenuated the production of inducible nitric oxide synthase and phosphorylation of inhibitor of κB and nuclear factor-κB after reperfusion, which were more prominent under hyperglycemia. Conclusions: Propofol conveyed renoprotection against IR injury by preserved antioxidation ability and attenuated inflammatory response, which were more prominent under hyperglycemia.

Original languageEnglish
Pages (from-to)783-791
Number of pages9
JournalJournal of Surgical Research
Volume183
Issue number2
DOIs
Publication statusPublished - 2013 Aug

Bibliographical note

Funding Information:
Funding: This study was supported by a faculty research grant of Yonsei University College of Medicine (grant 6–2009–0090 ).

All Science Journal Classification (ASJC) codes

  • Surgery

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