Proposal for a standardized pathology report of gastroenteropancreatic neuroendocrine tumors

Prognostic significance of pathological parameters

Meeyon Cho, Jin Hee Sohn, So Young Jin, Hyunki Kim, Eun Sun Jung, Mi Jung Kim, Kyoung Mee Kim, Woo Ho Kim, Joon Mee Kim, Yun Kyung Kang, Joon Hyuk Choi, Dae Young Kang, Youn Wha Kim, Eun Hee Choi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients. Methods: We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report. Results: Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms. Conclusions: A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEPNET.

Original languageEnglish
Pages (from-to)227-237
Number of pages11
JournalKorean Journal of Pathology
Volume47
Issue number3
DOIs
Publication statusPublished - 2013 Aug 27

Fingerprint

Pathology
Chromogranins
Synaptophysin
Korea
Pancreatic Neoplasms
Mitosis
Joints
Lymph Nodes
Gastro-enteropancreatic neuroendocrine tumor
Neoplasm Metastasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Cho, Meeyon ; Sohn, Jin Hee ; Jin, So Young ; Kim, Hyunki ; Jung, Eun Sun ; Kim, Mi Jung ; Kim, Kyoung Mee ; Kim, Woo Ho ; Kim, Joon Mee ; Kang, Yun Kyung ; Choi, Joon Hyuk ; Kang, Dae Young ; Kim, Youn Wha ; Choi, Eun Hee. / Proposal for a standardized pathology report of gastroenteropancreatic neuroendocrine tumors : Prognostic significance of pathological parameters. In: Korean Journal of Pathology. 2013 ; Vol. 47, No. 3. pp. 227-237.
@article{be31cd06d26f4be1816f17bddfcfe9b8,
title = "Proposal for a standardized pathology report of gastroenteropancreatic neuroendocrine tumors: Prognostic significance of pathological parameters",
abstract = "Background: There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients. Methods: We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report. Results: Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms. Conclusions: A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEPNET.",
author = "Meeyon Cho and Sohn, {Jin Hee} and Jin, {So Young} and Hyunki Kim and Jung, {Eun Sun} and Kim, {Mi Jung} and Kim, {Kyoung Mee} and Kim, {Woo Ho} and Kim, {Joon Mee} and Kang, {Yun Kyung} and Choi, {Joon Hyuk} and Kang, {Dae Young} and Kim, {Youn Wha} and Choi, {Eun Hee}",
year = "2013",
month = "8",
day = "27",
doi = "10.4132/KoreanJPathol.2013.47.3.227",
language = "English",
volume = "47",
pages = "227--237",
journal = "Journal of Pathology and Translational Medicine",
issn = "2383-7837",
publisher = "Korean Society of Pathologists",
number = "3",

}

Cho, M, Sohn, JH, Jin, SY, Kim, H, Jung, ES, Kim, MJ, Kim, KM, Kim, WH, Kim, JM, Kang, YK, Choi, JH, Kang, DY, Kim, YW & Choi, EH 2013, 'Proposal for a standardized pathology report of gastroenteropancreatic neuroendocrine tumors: Prognostic significance of pathological parameters', Korean Journal of Pathology, vol. 47, no. 3, pp. 227-237. https://doi.org/10.4132/KoreanJPathol.2013.47.3.227

Proposal for a standardized pathology report of gastroenteropancreatic neuroendocrine tumors : Prognostic significance of pathological parameters. / Cho, Meeyon; Sohn, Jin Hee; Jin, So Young; Kim, Hyunki; Jung, Eun Sun; Kim, Mi Jung; Kim, Kyoung Mee; Kim, Woo Ho; Kim, Joon Mee; Kang, Yun Kyung; Choi, Joon Hyuk; Kang, Dae Young; Kim, Youn Wha; Choi, Eun Hee.

In: Korean Journal of Pathology, Vol. 47, No. 3, 27.08.2013, p. 227-237.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Proposal for a standardized pathology report of gastroenteropancreatic neuroendocrine tumors

T2 - Prognostic significance of pathological parameters

AU - Cho, Meeyon

AU - Sohn, Jin Hee

AU - Jin, So Young

AU - Kim, Hyunki

AU - Jung, Eun Sun

AU - Kim, Mi Jung

AU - Kim, Kyoung Mee

AU - Kim, Woo Ho

AU - Kim, Joon Mee

AU - Kang, Yun Kyung

AU - Choi, Joon Hyuk

AU - Kang, Dae Young

AU - Kim, Youn Wha

AU - Choi, Eun Hee

PY - 2013/8/27

Y1 - 2013/8/27

N2 - Background: There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients. Methods: We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report. Results: Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms. Conclusions: A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEPNET.

AB - Background: There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients. Methods: We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report. Results: Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms. Conclusions: A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEPNET.

UR - http://www.scopus.com/inward/record.url?scp=84882636077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882636077&partnerID=8YFLogxK

U2 - 10.4132/KoreanJPathol.2013.47.3.227

DO - 10.4132/KoreanJPathol.2013.47.3.227

M3 - Article

VL - 47

SP - 227

EP - 237

JO - Journal of Pathology and Translational Medicine

JF - Journal of Pathology and Translational Medicine

SN - 2383-7837

IS - 3

ER -