Prospective comparative study of endoscopic ultrasonography-guided fine-needle biopsy and unroofing biopsy

Jihye Park, Jun Chul Park, Jeong Hyeon Jo, Eun Hye Kim, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee

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Background and aim: Adequate tissue acquisition is important in making treatment decisions for patients with upper gastrointestinal subepithelial tumors (SETs). This study aimed to compare the outcomes of endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB)with those of the unroofing biopsy technique. Methods: This study was a single-center, prospective comparative study conducted at Severance Hospital, Yonsei University College of Medicine. A total of 39 patients with SETs ≥15 mm were enrolled between January 2016 and August 2017. Results: Of the 39 patients, 28 underwent biopsy with both techniques (4 underwent only unroofing and 7 underwent only EUS-FNB). Histological diagnosis was made with EUS-FNB in 64.3% and unroofing biopsy in 78.6% (p = 0.344), and immunohistochemical diagnosis was made with EUS-FNB in 46.4% and unroofing biopsy in 67.9% (p = 0.180). In the subgroup analysis (28 patients), there was no significant difference in diagnostic yield between the 2 methods The mean procedural time with EUS-FNB was shorter than that with unroofing biopsy (p < 0.001). The larger SET (≥ 20 mm)(p = 0.035)and satisfaction of procedure (p = 0.019)were positively associated with successful histological diagnosis by EUS-FNB. Conclusions: There was no significant difference in the histological diagnostic yield for SETs between the EUS-FNB and unroofing biopsy techniques ( identifier NCT02646241).

Original languageEnglish
Pages (from-to)831-836
Number of pages6
JournalDigestive and Liver Disease
Issue number6
Publication statusPublished - 2019 Jun


All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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