TY - JOUR
T1 - Prospective evaluation of the partially covered nitinol " ComVi" stent for malignant non hilar biliary obstruction
AU - Perri, Vincenzo
AU - Boškoski, Ivo
AU - Tringali, Andrea
AU - Familiari, Pietro
AU - Marchese, Michele
AU - Lee, Dong Ki
AU - Jang, Sung Il
AU - Han, Jimin
AU - Kim, Ho Gak
AU - Mutignani, Massimiliano
AU - Onder, Graziano
AU - Costamagna, Guido
PY - 2013/4
Y1 - 2013/4
N2 - Background: Biliary partially covered self-expandable metal stents (PC-SEMS) offer prolonged relief of symptoms of biliary obstruction but may induce complications including pancreatitis, cholecystitis and migration. Aims: To assess efficacy and safety of the ComVi partially covered self-expandable metal stents as primary palliative treatment of distal malignant biliary obstruction. Methods: Seventy patients (mean age 69.2 years) with distal malignant biliary strictures were prospectively included and underwent endoscopic retrograde cholangio-pancreatography and partially covered self-expandable metal stents placement. Follow-up was done for 12 months. self-expandable metal stents patency, survival and complication-rate after partially covered self-expandable metal stents placement were evaluated. Results: Overall median survival time was 190 days (30-856). Forty-four patients (62.8%) died after median 175.5 days (30-614) without signs of stent dysfunction; 37 patients (52.8%) were alive after 6 months without signs of self-expandable metal stents occlusion. Survival rapidly dropped between 8 and 12 months after treatment. Survival was not influenced by sex ( P= 0.1) or type of neoplasia ( P= 0.178). Median survival was longer (254 days [44-836]) in patients who underwent chemotherapy (. P<. 0.0001). Partially covered self-expandable metal stents occlusion had 24 (35.7%) patients 154 days (35-485) after treatment. Median survival after re-treatment was 66 days (13-597). Cholecystitis occurred in one patient (1.7%). Conclusions: The ComVi partially covered self-expandable metal stents is effective for palliation of biliary obstruction secondary to distal malignant biliary strictures. Self-expandable metal stents patency during follow-up is satisfactory without significant complications.
AB - Background: Biliary partially covered self-expandable metal stents (PC-SEMS) offer prolonged relief of symptoms of biliary obstruction but may induce complications including pancreatitis, cholecystitis and migration. Aims: To assess efficacy and safety of the ComVi partially covered self-expandable metal stents as primary palliative treatment of distal malignant biliary obstruction. Methods: Seventy patients (mean age 69.2 years) with distal malignant biliary strictures were prospectively included and underwent endoscopic retrograde cholangio-pancreatography and partially covered self-expandable metal stents placement. Follow-up was done for 12 months. self-expandable metal stents patency, survival and complication-rate after partially covered self-expandable metal stents placement were evaluated. Results: Overall median survival time was 190 days (30-856). Forty-four patients (62.8%) died after median 175.5 days (30-614) without signs of stent dysfunction; 37 patients (52.8%) were alive after 6 months without signs of self-expandable metal stents occlusion. Survival rapidly dropped between 8 and 12 months after treatment. Survival was not influenced by sex ( P= 0.1) or type of neoplasia ( P= 0.178). Median survival was longer (254 days [44-836]) in patients who underwent chemotherapy (. P<. 0.0001). Partially covered self-expandable metal stents occlusion had 24 (35.7%) patients 154 days (35-485) after treatment. Median survival after re-treatment was 66 days (13-597). Cholecystitis occurred in one patient (1.7%). Conclusions: The ComVi partially covered self-expandable metal stents is effective for palliation of biliary obstruction secondary to distal malignant biliary strictures. Self-expandable metal stents patency during follow-up is satisfactory without significant complications.
UR - http://www.scopus.com/inward/record.url?scp=84875245283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875245283&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2012.11.001
DO - 10.1016/j.dld.2012.11.001
M3 - Article
C2 - 23218991
AN - SCOPUS:84875245283
VL - 45
SP - 305
EP - 309
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 4
ER -