Prostate cancer in Korean men exhibits poor differentiation and is adversely related to prognosis after radical prostatectomy

Cheryn Song, Jae Y. Ro, Moo Song Lee, Sung Joon Hong, Byungha Chung, Han Yong Choi, Sang Eun Lee, Eunsik Lee, Choung Soo Kim, Hanjong Ahn

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Abstract

Objectives: To investigate the clinical and pathologic characteristics of prostate cancer in Korean men to determine how ethnic differences affect clinical outcome. Methods: The clinical and pathologic data of 604 Korean men who underwent radical prostatectomy from 1994 to 2003 were reviewed. Biochemical failure was defined as a prostate-specific antigen (PSA) level of 0.2 ng/mL or greater on two consecutive occasions after having achieved an undetectable PSA level. Patient distribution with respect to the clinical and pathologic parameters and biochemical failure rates were compared with those of contemporary Western series. Results: The mean preoperative PSA level was 9.9 ng/mL (range 0.4 to 38.8) and the median biopsy Gleason score was 7. The Gleason score was 7 in 186 patients (30.8%) and greater than 7 in 169 (28.0%). Gleason scores stratified with respect to clinical stage and PSA range revealed the proportion of patients with high Gleason scores (7 or greater) to be more than 50% of each subgroup throughout the clinical stages and PSA ranges. At a median follow-up of 57.9 months (range 22 to 131), biochemical failure occurred in 24.2% of all patients and in 14.3% of those with an initial serum PSA level of 10.0 ng/mL or lower. On multivariate Cox regression analysis, the Gleason score showed the strongest statistical significance for biochemical failure (P = 0.001, hazard ratio 1.376, 95% confidence interval 1.056 to 1.792) for patients with a serum PSA level of 10.0 ng/mL or lower. Conclusions: A significant proportion of prostate cancers arising in Korean men exhibit poor differentiation, regardless of the initial serum PSA level or clinical stage at presentation, and adversely affect prognosis, causing a greater rate of PSA failure.

Original languageEnglish
Pages (from-to)820-824
Number of pages5
JournalUrology
Volume68
Issue number4
DOIs
Publication statusPublished - 2006 Oct 1

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Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
Neoplasm Grading
Serum
Regression Analysis
Confidence Intervals
Biopsy

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Song, Cheryn ; Ro, Jae Y. ; Lee, Moo Song ; Hong, Sung Joon ; Chung, Byungha ; Choi, Han Yong ; Lee, Sang Eun ; Lee, Eunsik ; Kim, Choung Soo ; Ahn, Hanjong. / Prostate cancer in Korean men exhibits poor differentiation and is adversely related to prognosis after radical prostatectomy. In: Urology. 2006 ; Vol. 68, No. 4. pp. 820-824.
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abstract = "Objectives: To investigate the clinical and pathologic characteristics of prostate cancer in Korean men to determine how ethnic differences affect clinical outcome. Methods: The clinical and pathologic data of 604 Korean men who underwent radical prostatectomy from 1994 to 2003 were reviewed. Biochemical failure was defined as a prostate-specific antigen (PSA) level of 0.2 ng/mL or greater on two consecutive occasions after having achieved an undetectable PSA level. Patient distribution with respect to the clinical and pathologic parameters and biochemical failure rates were compared with those of contemporary Western series. Results: The mean preoperative PSA level was 9.9 ng/mL (range 0.4 to 38.8) and the median biopsy Gleason score was 7. The Gleason score was 7 in 186 patients (30.8{\%}) and greater than 7 in 169 (28.0{\%}). Gleason scores stratified with respect to clinical stage and PSA range revealed the proportion of patients with high Gleason scores (7 or greater) to be more than 50{\%} of each subgroup throughout the clinical stages and PSA ranges. At a median follow-up of 57.9 months (range 22 to 131), biochemical failure occurred in 24.2{\%} of all patients and in 14.3{\%} of those with an initial serum PSA level of 10.0 ng/mL or lower. On multivariate Cox regression analysis, the Gleason score showed the strongest statistical significance for biochemical failure (P = 0.001, hazard ratio 1.376, 95{\%} confidence interval 1.056 to 1.792) for patients with a serum PSA level of 10.0 ng/mL or lower. Conclusions: A significant proportion of prostate cancers arising in Korean men exhibit poor differentiation, regardless of the initial serum PSA level or clinical stage at presentation, and adversely affect prognosis, causing a greater rate of PSA failure.",
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Prostate cancer in Korean men exhibits poor differentiation and is adversely related to prognosis after radical prostatectomy. / Song, Cheryn; Ro, Jae Y.; Lee, Moo Song; Hong, Sung Joon; Chung, Byungha; Choi, Han Yong; Lee, Sang Eun; Lee, Eunsik; Kim, Choung Soo; Ahn, Hanjong.

In: Urology, Vol. 68, No. 4, 01.10.2006, p. 820-824.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prostate cancer in Korean men exhibits poor differentiation and is adversely related to prognosis after radical prostatectomy

AU - Song, Cheryn

AU - Ro, Jae Y.

AU - Lee, Moo Song

AU - Hong, Sung Joon

AU - Chung, Byungha

AU - Choi, Han Yong

AU - Lee, Sang Eun

AU - Lee, Eunsik

AU - Kim, Choung Soo

AU - Ahn, Hanjong

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Objectives: To investigate the clinical and pathologic characteristics of prostate cancer in Korean men to determine how ethnic differences affect clinical outcome. Methods: The clinical and pathologic data of 604 Korean men who underwent radical prostatectomy from 1994 to 2003 were reviewed. Biochemical failure was defined as a prostate-specific antigen (PSA) level of 0.2 ng/mL or greater on two consecutive occasions after having achieved an undetectable PSA level. Patient distribution with respect to the clinical and pathologic parameters and biochemical failure rates were compared with those of contemporary Western series. Results: The mean preoperative PSA level was 9.9 ng/mL (range 0.4 to 38.8) and the median biopsy Gleason score was 7. The Gleason score was 7 in 186 patients (30.8%) and greater than 7 in 169 (28.0%). Gleason scores stratified with respect to clinical stage and PSA range revealed the proportion of patients with high Gleason scores (7 or greater) to be more than 50% of each subgroup throughout the clinical stages and PSA ranges. At a median follow-up of 57.9 months (range 22 to 131), biochemical failure occurred in 24.2% of all patients and in 14.3% of those with an initial serum PSA level of 10.0 ng/mL or lower. On multivariate Cox regression analysis, the Gleason score showed the strongest statistical significance for biochemical failure (P = 0.001, hazard ratio 1.376, 95% confidence interval 1.056 to 1.792) for patients with a serum PSA level of 10.0 ng/mL or lower. Conclusions: A significant proportion of prostate cancers arising in Korean men exhibit poor differentiation, regardless of the initial serum PSA level or clinical stage at presentation, and adversely affect prognosis, causing a greater rate of PSA failure.

AB - Objectives: To investigate the clinical and pathologic characteristics of prostate cancer in Korean men to determine how ethnic differences affect clinical outcome. Methods: The clinical and pathologic data of 604 Korean men who underwent radical prostatectomy from 1994 to 2003 were reviewed. Biochemical failure was defined as a prostate-specific antigen (PSA) level of 0.2 ng/mL or greater on two consecutive occasions after having achieved an undetectable PSA level. Patient distribution with respect to the clinical and pathologic parameters and biochemical failure rates were compared with those of contemporary Western series. Results: The mean preoperative PSA level was 9.9 ng/mL (range 0.4 to 38.8) and the median biopsy Gleason score was 7. The Gleason score was 7 in 186 patients (30.8%) and greater than 7 in 169 (28.0%). Gleason scores stratified with respect to clinical stage and PSA range revealed the proportion of patients with high Gleason scores (7 or greater) to be more than 50% of each subgroup throughout the clinical stages and PSA ranges. At a median follow-up of 57.9 months (range 22 to 131), biochemical failure occurred in 24.2% of all patients and in 14.3% of those with an initial serum PSA level of 10.0 ng/mL or lower. On multivariate Cox regression analysis, the Gleason score showed the strongest statistical significance for biochemical failure (P = 0.001, hazard ratio 1.376, 95% confidence interval 1.056 to 1.792) for patients with a serum PSA level of 10.0 ng/mL or lower. Conclusions: A significant proportion of prostate cancers arising in Korean men exhibit poor differentiation, regardless of the initial serum PSA level or clinical stage at presentation, and adversely affect prognosis, causing a greater rate of PSA failure.

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