Prostate size correlates with fasting blood glucose in non- diabetic benign prostatic hyperplasia patients with normal testosterone levels

Won Tae Kim, Seok Joong Yun, Young Deuk Choi, Gi Young Kim, Sung Kwon Moon, Yung Hyun Choi, Isaac Yi Kim, Wun Jae Kim

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18 Citations (Scopus)

Abstract

We evaluated the correlations between BMI, fasting glucose, insulin, testosterone level, insulin resistance, and prostate size in non-diabetic benign prostatic hyperplasia (BPH) patients with normal testosterone levels. Data from 212 non-diabetic BPH patients with normal testosterone levels, who underwent transurethral resection of the prostate (TURP) due to medical treatment failure, were evaluated retrospectively. Patients with prostate specific antigen (PSA) levels of ≥ 3 ng/mL underwent multicore transrectal prostate biopsy before TURP to rule out prostate cancer. Patients with diabetes mellitus (DM) or serum testosterone levels of < 3.50 ng/mL were excluded from analysis. Correlations between clinical and laboratory parameters were determined. Prostate size correlated positively with age (r = 0.227, P < 0.001), PSA (r = 0.510, P < 0.001), and fasting glucose level (r = 0.186, P = 0.007), but not with BMI, testosterone, insulin level, or insulin resistance (each P > 0.05). Testosterone level inversely correlated with BMI (r = -0.327, P < 0.001), insulin level (r = -0.207, P = 0.003), and insulin resistance (r = -0.221, P = 0.001), but not with age, prostate size, PSA, or fasting glucose level (each P > 0.05). Upon multiple adjusted linear regression analysis, prostate size correlated with elevated PSA (P < 0.001) and increased fasting glucose levels (P = 0.023). In non-DM BPH patients with normal testosterone levels, fasting glucose level is an independent risk factor for prostate hyperplasia.

Original languageEnglish
Pages (from-to)1214-1218
Number of pages5
JournalJournal of Korean medical science
Volume26
Issue number9
DOIs
Publication statusPublished - 2011 Sep 1

Fingerprint

Prostatic Hyperplasia
Blood Glucose
Testosterone
Prostate
Fasting
Transurethral Resection of Prostate
Prostate-Specific Antigen
Glucose
Treatment Failure
Hyperplasia
Insulin Resistance
Linear Models
Prostatic Neoplasms
Diabetes Mellitus
Regression Analysis
Insulin
Biopsy
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Won Tae ; Yun, Seok Joong ; Choi, Young Deuk ; Kim, Gi Young ; Moon, Sung Kwon ; Choi, Yung Hyun ; Kim, Isaac Yi ; Kim, Wun Jae. / Prostate size correlates with fasting blood glucose in non- diabetic benign prostatic hyperplasia patients with normal testosterone levels. In: Journal of Korean medical science. 2011 ; Vol. 26, No. 9. pp. 1214-1218.
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Prostate size correlates with fasting blood glucose in non- diabetic benign prostatic hyperplasia patients with normal testosterone levels. / Kim, Won Tae; Yun, Seok Joong; Choi, Young Deuk; Kim, Gi Young; Moon, Sung Kwon; Choi, Yung Hyun; Kim, Isaac Yi; Kim, Wun Jae.

In: Journal of Korean medical science, Vol. 26, No. 9, 01.09.2011, p. 1214-1218.

Research output: Contribution to journalArticle

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