Abstract
Green tea polyphenols (GTPs) are well known as functional foods with variousbioactivities. Conventional studies have typically focused on antioxidant, anticancer,anti-inflammatory and antimicrobial effects of GTPs. Para-hydroxyl, catechol and galloylgroups of catechins are mainly responsible for these biological activities. A newpromising field in polyphenols research is the study on the use of GTPs for non-frozenpreservation of mammalian cells and tissues. This chapter therefore concentrates on thebeneficial cardiovascular effects of GTPs, especially on those aspects related to theprotection and preservation of vascular cells and tissues. In the first part, we give anoverview of the antioxidant activity of GTPs in protection of endothelial cells (ECs) andblood vessels from reactive oxygen species-induced injury. We then discuss the antiproliferativeactivity of GTPs to prevent abnormal growth and migration of vascularsmooth muscle cells (VSMCs) that are involved in vascular diseases, includingatherosclerosis and re-stenosis after angioplasty. We finally argue in favor of thepotential usability of GTPs in the preservation of vascular tissues under physiologicalconditions. Pre-treatment with GTPs can indeed protect human ECs and saphenous vein against oxidative stress. Treatment with epigallocatechin-3-O-gallate (EGCG), a majorpolyphenolic constituent of green tea, also results in significant inhibition of attachment,proliferation and migration as well as cell-cycle arrest in serum-stimulated VSMCs.Moreover, these behaviors of VSMCs are effectively suppressed onto EGCG-releasingbiodegradable polymers that might be applied for the development of an EGCG-elutingvascular stent. Furthermore, GTP-pretreated veins can be preserved in a non-frozen statefor at least 2 wk, maintaining their vascular cell viability and vasculature without anystructural alterations. Therefore, GTPs may be usefully exploited to establish strategiesfor the protection and preservation of ECs and vascular tissues.
| Original language | English |
|---|---|
| Title of host publication | Polyphenols and Health |
| Subtitle of host publication | New and Recent Advances |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 87-111 |
| Number of pages | 25 |
| ISBN (Print) | 9781604563498 |
| Publication status | Published - 2008 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
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Protection and preservation of vascular cells and tissues by green tea polyphenols. / Han, Dong Wook; Hyon, Suong Hyu; Park, Jongchul.
Polyphenols and Health: New and Recent Advances. Nova Science Publishers, Inc., 2008. p. 87-111.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Protection and preservation of vascular cells and tissues by green tea polyphenols
AU - Han, Dong Wook
AU - Hyon, Suong Hyu
AU - Park, Jongchul
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Green tea polyphenols (GTPs) are well known as functional foods with variousbioactivities. Conventional studies have typically focused on antioxidant, anticancer,anti-inflammatory and antimicrobial effects of GTPs. Para-hydroxyl, catechol and galloylgroups of catechins are mainly responsible for these biological activities. A newpromising field in polyphenols research is the study on the use of GTPs for non-frozenpreservation of mammalian cells and tissues. This chapter therefore concentrates on thebeneficial cardiovascular effects of GTPs, especially on those aspects related to theprotection and preservation of vascular cells and tissues. In the first part, we give anoverview of the antioxidant activity of GTPs in protection of endothelial cells (ECs) andblood vessels from reactive oxygen species-induced injury. We then discuss the antiproliferativeactivity of GTPs to prevent abnormal growth and migration of vascularsmooth muscle cells (VSMCs) that are involved in vascular diseases, includingatherosclerosis and re-stenosis after angioplasty. We finally argue in favor of thepotential usability of GTPs in the preservation of vascular tissues under physiologicalconditions. Pre-treatment with GTPs can indeed protect human ECs and saphenous vein against oxidative stress. Treatment with epigallocatechin-3-O-gallate (EGCG), a majorpolyphenolic constituent of green tea, also results in significant inhibition of attachment,proliferation and migration as well as cell-cycle arrest in serum-stimulated VSMCs.Moreover, these behaviors of VSMCs are effectively suppressed onto EGCG-releasingbiodegradable polymers that might be applied for the development of an EGCG-elutingvascular stent. Furthermore, GTP-pretreated veins can be preserved in a non-frozen statefor at least 2 wk, maintaining their vascular cell viability and vasculature without anystructural alterations. Therefore, GTPs may be usefully exploited to establish strategiesfor the protection and preservation of ECs and vascular tissues.
AB - Green tea polyphenols (GTPs) are well known as functional foods with variousbioactivities. Conventional studies have typically focused on antioxidant, anticancer,anti-inflammatory and antimicrobial effects of GTPs. Para-hydroxyl, catechol and galloylgroups of catechins are mainly responsible for these biological activities. A newpromising field in polyphenols research is the study on the use of GTPs for non-frozenpreservation of mammalian cells and tissues. This chapter therefore concentrates on thebeneficial cardiovascular effects of GTPs, especially on those aspects related to theprotection and preservation of vascular cells and tissues. In the first part, we give anoverview of the antioxidant activity of GTPs in protection of endothelial cells (ECs) andblood vessels from reactive oxygen species-induced injury. We then discuss the antiproliferativeactivity of GTPs to prevent abnormal growth and migration of vascularsmooth muscle cells (VSMCs) that are involved in vascular diseases, includingatherosclerosis and re-stenosis after angioplasty. We finally argue in favor of thepotential usability of GTPs in the preservation of vascular tissues under physiologicalconditions. Pre-treatment with GTPs can indeed protect human ECs and saphenous vein against oxidative stress. Treatment with epigallocatechin-3-O-gallate (EGCG), a majorpolyphenolic constituent of green tea, also results in significant inhibition of attachment,proliferation and migration as well as cell-cycle arrest in serum-stimulated VSMCs.Moreover, these behaviors of VSMCs are effectively suppressed onto EGCG-releasingbiodegradable polymers that might be applied for the development of an EGCG-elutingvascular stent. Furthermore, GTP-pretreated veins can be preserved in a non-frozen statefor at least 2 wk, maintaining their vascular cell viability and vasculature without anystructural alterations. Therefore, GTPs may be usefully exploited to establish strategiesfor the protection and preservation of ECs and vascular tissues.
UR - http://www.scopus.com/inward/record.url?scp=78649487838&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649487838&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:78649487838
SN - 9781604563498
SP - 87
EP - 111
BT - Polyphenols and Health
PB - Nova Science Publishers, Inc.
ER -