Protection Process of the tert-Butyl Group as a Non-Polar Moiety of D-Serine: Unexpected Rearrangement

Bo Eun Choi, Jin Hyun Jeong

Research output: Contribution to journalArticle

Abstract

The use of amino acid derivatives as building blocks in peptide synthesis is increasingly being recognized as a potential route for the development of pharmaceutical agents. Side chain protection of polyfunctional amino acids such as Ser, Thr, Tyr is viewed as being particularly important. Although these derivatives are commercially listed, they are expensive and not widely available. We describe here a practical large-scale synthesis of t-butyl introduced Dserine, one of the building blocks of zoladex, a peptide drug. D-Serine, Peptide synthesis, Protecting group, t-Butyl ether, t-Butyl ester.

Original languageEnglish
Pages (from-to)564-567
Number of pages4
JournalArchives of pharmacal research
Volume23
Issue number6
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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