The use of amino acid derivatives as building blocks in peptide synthesis is increasingly being recognized as a potential route for the development of pharmaceutical agents. Side chain protection of polyfunctional amino acids such as Ser, Thr, Tyr is viewed as being particularly important. Although these derivatives are commercially listed, they are expensive and not widely available. We describe here a practical large-scale synthesis of t-butyl introduced Dserine, one of the building blocks of zoladex, a peptide drug. D-Serine, Peptide synthesis, Protecting group, t-Butyl ether, t-Butyl ester.
Bibliographical noteFunding Information:
This research was supported in part by the grant from Brain Korea 21 project and Korea Science and Engineering Foundation.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery
- Organic Chemistry