Protective effects of haematococcus astaxanthin on oxidative stress in healthy smokers

Ji Hae Kim, Min Jung Chang, Hye Duck Choi, Yeo Kyu Youn, Jung Tae Kim, Jung Mi Oh, Wan Gyoon Shin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Free radicals induced by cigarette smoking have been strongly linked to increased oxidative stress in vivo, contributing to the pathobiology of various diseases. This study was performed to investigate the effects of Haematococcus astaxanthin (ASX), which has been known to be a potent antioxidant, on oxidative stress in smokers. Thirty-nine heavy smokers (≥20 cigarettes/day) and 39 non-smokers were enrolled in this study. Smokers were randomly divided into three dosage groups to receive ASX at doses of 5, 20, or 40mg (n=13, each) once daily for 3 weeks. Oxidative stress biomarkers such as malondialdehyde, isoprostane, superoxide dismutase, and total antioxidant capacity, and ASX levels in plasma were measured at baseline and after 1, 2, and 3 weeks of treatment. Compared with baseline, the plasma malondialdehyde and isoprostane levels decreased, whereas superoxide dismutase level and total antioxidant capacity increased in all ASX intervention groups over the 3-week period. In particular, isoprostane levels showed a significant dose-dependent decrease after ASX intake. The results suggest that ASX supplementation might prevent oxidative damage in smokers by suppressing lipid peroxidation and stimulating the activity of the antioxidant system in smokers.

Original languageEnglish
Pages (from-to)1469-1475
Number of pages7
JournalJournal of Medicinal Food
Volume14
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

Fingerprint

Oxidative Stress
Isoprostanes
Antioxidants
Malondialdehyde
Superoxide Dismutase
Tobacco Products
Lipid Peroxidation
Free Radicals
astaxanthine
Biomarkers
Smoking

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Kim, Ji Hae ; Chang, Min Jung ; Choi, Hye Duck ; Youn, Yeo Kyu ; Kim, Jung Tae ; Oh, Jung Mi ; Shin, Wan Gyoon. / Protective effects of haematococcus astaxanthin on oxidative stress in healthy smokers. In: Journal of Medicinal Food. 2011 ; Vol. 14, No. 11. pp. 1469-1475.
@article{039e9550bc814d44a448972e8bdd5852,
title = "Protective effects of haematococcus astaxanthin on oxidative stress in healthy smokers",
abstract = "Free radicals induced by cigarette smoking have been strongly linked to increased oxidative stress in vivo, contributing to the pathobiology of various diseases. This study was performed to investigate the effects of Haematococcus astaxanthin (ASX), which has been known to be a potent antioxidant, on oxidative stress in smokers. Thirty-nine heavy smokers (≥20 cigarettes/day) and 39 non-smokers were enrolled in this study. Smokers were randomly divided into three dosage groups to receive ASX at doses of 5, 20, or 40mg (n=13, each) once daily for 3 weeks. Oxidative stress biomarkers such as malondialdehyde, isoprostane, superoxide dismutase, and total antioxidant capacity, and ASX levels in plasma were measured at baseline and after 1, 2, and 3 weeks of treatment. Compared with baseline, the plasma malondialdehyde and isoprostane levels decreased, whereas superoxide dismutase level and total antioxidant capacity increased in all ASX intervention groups over the 3-week period. In particular, isoprostane levels showed a significant dose-dependent decrease after ASX intake. The results suggest that ASX supplementation might prevent oxidative damage in smokers by suppressing lipid peroxidation and stimulating the activity of the antioxidant system in smokers.",
author = "Kim, {Ji Hae} and Chang, {Min Jung} and Choi, {Hye Duck} and Youn, {Yeo Kyu} and Kim, {Jung Tae} and Oh, {Jung Mi} and Shin, {Wan Gyoon}",
year = "2011",
month = "11",
day = "1",
doi = "10.1089/jmf.2011.1626",
language = "English",
volume = "14",
pages = "1469--1475",
journal = "Journal of Medicinal Food",
issn = "1096-620X",
publisher = "Mary Ann Liebert Inc.",
number = "11",

}

Protective effects of haematococcus astaxanthin on oxidative stress in healthy smokers. / Kim, Ji Hae; Chang, Min Jung; Choi, Hye Duck; Youn, Yeo Kyu; Kim, Jung Tae; Oh, Jung Mi; Shin, Wan Gyoon.

In: Journal of Medicinal Food, Vol. 14, No. 11, 01.11.2011, p. 1469-1475.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protective effects of haematococcus astaxanthin on oxidative stress in healthy smokers

AU - Kim, Ji Hae

AU - Chang, Min Jung

AU - Choi, Hye Duck

AU - Youn, Yeo Kyu

AU - Kim, Jung Tae

AU - Oh, Jung Mi

AU - Shin, Wan Gyoon

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Free radicals induced by cigarette smoking have been strongly linked to increased oxidative stress in vivo, contributing to the pathobiology of various diseases. This study was performed to investigate the effects of Haematococcus astaxanthin (ASX), which has been known to be a potent antioxidant, on oxidative stress in smokers. Thirty-nine heavy smokers (≥20 cigarettes/day) and 39 non-smokers were enrolled in this study. Smokers were randomly divided into three dosage groups to receive ASX at doses of 5, 20, or 40mg (n=13, each) once daily for 3 weeks. Oxidative stress biomarkers such as malondialdehyde, isoprostane, superoxide dismutase, and total antioxidant capacity, and ASX levels in plasma were measured at baseline and after 1, 2, and 3 weeks of treatment. Compared with baseline, the plasma malondialdehyde and isoprostane levels decreased, whereas superoxide dismutase level and total antioxidant capacity increased in all ASX intervention groups over the 3-week period. In particular, isoprostane levels showed a significant dose-dependent decrease after ASX intake. The results suggest that ASX supplementation might prevent oxidative damage in smokers by suppressing lipid peroxidation and stimulating the activity of the antioxidant system in smokers.

AB - Free radicals induced by cigarette smoking have been strongly linked to increased oxidative stress in vivo, contributing to the pathobiology of various diseases. This study was performed to investigate the effects of Haematococcus astaxanthin (ASX), which has been known to be a potent antioxidant, on oxidative stress in smokers. Thirty-nine heavy smokers (≥20 cigarettes/day) and 39 non-smokers were enrolled in this study. Smokers were randomly divided into three dosage groups to receive ASX at doses of 5, 20, or 40mg (n=13, each) once daily for 3 weeks. Oxidative stress biomarkers such as malondialdehyde, isoprostane, superoxide dismutase, and total antioxidant capacity, and ASX levels in plasma were measured at baseline and after 1, 2, and 3 weeks of treatment. Compared with baseline, the plasma malondialdehyde and isoprostane levels decreased, whereas superoxide dismutase level and total antioxidant capacity increased in all ASX intervention groups over the 3-week period. In particular, isoprostane levels showed a significant dose-dependent decrease after ASX intake. The results suggest that ASX supplementation might prevent oxidative damage in smokers by suppressing lipid peroxidation and stimulating the activity of the antioxidant system in smokers.

UR - http://www.scopus.com/inward/record.url?scp=80755125216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80755125216&partnerID=8YFLogxK

U2 - 10.1089/jmf.2011.1626

DO - 10.1089/jmf.2011.1626

M3 - Article

VL - 14

SP - 1469

EP - 1475

JO - Journal of Medicinal Food

JF - Journal of Medicinal Food

SN - 1096-620X

IS - 11

ER -