Protective effects of vitamin E on chemotherapy-induced peripheral neuropathy

A meta-analysis of rando-mized controlled trials

Seenae Eum, Hye Duck Choi, Min Jung Chang, Ho Chun Choi, Young Jin Ko, Jeong Soo Ahn, Wan Gyoon Shin, Ju Yeun Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: This study aimed to investigate the neuroprotective effects of vitamin E for preventing chemotherapy-induced peripheral neuropathy (CIPN). Methods: A comprehensive search from 1973 through July 2011 identified randomized controlled trials (RCTs) that reported the preventive effects of vitamin E on CIPN. The relative risk (RR) of CIPN with vitamin E supplementation, comparedwith placebo, was assessed with the Bayesian random effect model and expressed as RR with a 95 %credible-interval (CrI). Bayesian outcome probabilities were calculated as the probability (P) of RR <1. Results: Five RCTs, involving 319 patients, were identified. Upon pooling these RCTs, vitamin E supplementation (300-600 mg/day) had a significant effect on CIPN prevention (RR 0.43; 95 % CrI 0.10-1.00, P = 97.5 %). Subgroup analysis by chemotherapeutic agent type was only available for cisplatin and showed that vitamin E supplementation significantly reduced the incidence of CIPN (RR 0.26; 95 % CrI 0.06-0.89, P = 98.1 %). Furthermore, there were no adverse effects caused by vitamin E supplementation in any of the RCTs. Conclusion: Available data included in this meta-analysis show that vitamin E supplementation might significantly prevent CIPN. Currently, however, the data are insufficient to confidently conclude the true value. Large-scale, rigorously designed RCTs are needed to confirm the role of vitamin E supplementation in CIPN prevention.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
JournalInternational Journal for Vitamin and Nutrition Research
Volume83
Issue number2
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Peripheral Nervous System Diseases
Vitamin E
Meta-Analysis
Drug Therapy
Randomized Controlled Trials
Neuroprotective Agents
Cisplatin
Placebos
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Eum, Seenae ; Choi, Hye Duck ; Chang, Min Jung ; Choi, Ho Chun ; Ko, Young Jin ; Ahn, Jeong Soo ; Shin, Wan Gyoon ; Lee, Ju Yeun. / Protective effects of vitamin E on chemotherapy-induced peripheral neuropathy : A meta-analysis of rando-mized controlled trials. In: International Journal for Vitamin and Nutrition Research. 2013 ; Vol. 83, No. 2. pp. 101-111.
@article{b42bd85258f4474a9b7c816271c23b86,
title = "Protective effects of vitamin E on chemotherapy-induced peripheral neuropathy: A meta-analysis of rando-mized controlled trials",
abstract = "Purpose: This study aimed to investigate the neuroprotective effects of vitamin E for preventing chemotherapy-induced peripheral neuropathy (CIPN). Methods: A comprehensive search from 1973 through July 2011 identified randomized controlled trials (RCTs) that reported the preventive effects of vitamin E on CIPN. The relative risk (RR) of CIPN with vitamin E supplementation, comparedwith placebo, was assessed with the Bayesian random effect model and expressed as RR with a 95 {\%}credible-interval (CrI). Bayesian outcome probabilities were calculated as the probability (P) of RR <1. Results: Five RCTs, involving 319 patients, were identified. Upon pooling these RCTs, vitamin E supplementation (300-600 mg/day) had a significant effect on CIPN prevention (RR 0.43; 95 {\%} CrI 0.10-1.00, P = 97.5 {\%}). Subgroup analysis by chemotherapeutic agent type was only available for cisplatin and showed that vitamin E supplementation significantly reduced the incidence of CIPN (RR 0.26; 95 {\%} CrI 0.06-0.89, P = 98.1 {\%}). Furthermore, there were no adverse effects caused by vitamin E supplementation in any of the RCTs. Conclusion: Available data included in this meta-analysis show that vitamin E supplementation might significantly prevent CIPN. Currently, however, the data are insufficient to confidently conclude the true value. Large-scale, rigorously designed RCTs are needed to confirm the role of vitamin E supplementation in CIPN prevention.",
author = "Seenae Eum and Choi, {Hye Duck} and Chang, {Min Jung} and Choi, {Ho Chun} and Ko, {Young Jin} and Ahn, {Jeong Soo} and Shin, {Wan Gyoon} and Lee, {Ju Yeun}",
year = "2013",
month = "1",
day = "1",
doi = "10.1024/0300-9831/a000149",
language = "English",
volume = "83",
pages = "101--111",
journal = "Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie",
issn = "0300-9831",
publisher = "Verlag Hans Huber",
number = "2",

}

Protective effects of vitamin E on chemotherapy-induced peripheral neuropathy : A meta-analysis of rando-mized controlled trials. / Eum, Seenae; Choi, Hye Duck; Chang, Min Jung; Choi, Ho Chun; Ko, Young Jin; Ahn, Jeong Soo; Shin, Wan Gyoon; Lee, Ju Yeun.

In: International Journal for Vitamin and Nutrition Research, Vol. 83, No. 2, 01.01.2013, p. 101-111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protective effects of vitamin E on chemotherapy-induced peripheral neuropathy

T2 - A meta-analysis of rando-mized controlled trials

AU - Eum, Seenae

AU - Choi, Hye Duck

AU - Chang, Min Jung

AU - Choi, Ho Chun

AU - Ko, Young Jin

AU - Ahn, Jeong Soo

AU - Shin, Wan Gyoon

AU - Lee, Ju Yeun

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Purpose: This study aimed to investigate the neuroprotective effects of vitamin E for preventing chemotherapy-induced peripheral neuropathy (CIPN). Methods: A comprehensive search from 1973 through July 2011 identified randomized controlled trials (RCTs) that reported the preventive effects of vitamin E on CIPN. The relative risk (RR) of CIPN with vitamin E supplementation, comparedwith placebo, was assessed with the Bayesian random effect model and expressed as RR with a 95 %credible-interval (CrI). Bayesian outcome probabilities were calculated as the probability (P) of RR <1. Results: Five RCTs, involving 319 patients, were identified. Upon pooling these RCTs, vitamin E supplementation (300-600 mg/day) had a significant effect on CIPN prevention (RR 0.43; 95 % CrI 0.10-1.00, P = 97.5 %). Subgroup analysis by chemotherapeutic agent type was only available for cisplatin and showed that vitamin E supplementation significantly reduced the incidence of CIPN (RR 0.26; 95 % CrI 0.06-0.89, P = 98.1 %). Furthermore, there were no adverse effects caused by vitamin E supplementation in any of the RCTs. Conclusion: Available data included in this meta-analysis show that vitamin E supplementation might significantly prevent CIPN. Currently, however, the data are insufficient to confidently conclude the true value. Large-scale, rigorously designed RCTs are needed to confirm the role of vitamin E supplementation in CIPN prevention.

AB - Purpose: This study aimed to investigate the neuroprotective effects of vitamin E for preventing chemotherapy-induced peripheral neuropathy (CIPN). Methods: A comprehensive search from 1973 through July 2011 identified randomized controlled trials (RCTs) that reported the preventive effects of vitamin E on CIPN. The relative risk (RR) of CIPN with vitamin E supplementation, comparedwith placebo, was assessed with the Bayesian random effect model and expressed as RR with a 95 %credible-interval (CrI). Bayesian outcome probabilities were calculated as the probability (P) of RR <1. Results: Five RCTs, involving 319 patients, were identified. Upon pooling these RCTs, vitamin E supplementation (300-600 mg/day) had a significant effect on CIPN prevention (RR 0.43; 95 % CrI 0.10-1.00, P = 97.5 %). Subgroup analysis by chemotherapeutic agent type was only available for cisplatin and showed that vitamin E supplementation significantly reduced the incidence of CIPN (RR 0.26; 95 % CrI 0.06-0.89, P = 98.1 %). Furthermore, there were no adverse effects caused by vitamin E supplementation in any of the RCTs. Conclusion: Available data included in this meta-analysis show that vitamin E supplementation might significantly prevent CIPN. Currently, however, the data are insufficient to confidently conclude the true value. Large-scale, rigorously designed RCTs are needed to confirm the role of vitamin E supplementation in CIPN prevention.

UR - http://www.scopus.com/inward/record.url?scp=84896721500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896721500&partnerID=8YFLogxK

U2 - 10.1024/0300-9831/a000149

DO - 10.1024/0300-9831/a000149

M3 - Article

VL - 83

SP - 101

EP - 111

JO - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie

JF - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie

SN - 0300-9831

IS - 2

ER -