Protective role of adipose-derived stem cells and their soluble factors in photoaging

Won Serk Kim, Byung Soon Park, Jong Hyuk Sung

Research output: Contribution to journalShort survey

95 Citations (Scopus)

Abstract

As individuals age, the skin undergoes changes, such as irregular pigmentation, thinning and loss of elasticity, that are due to both genetic and environmental factors. These changes may worsen, progressing to precancerous and cancerous diseases. Various medical treatments and topical cosmeceuticals have been used to treat some symptoms of photoaging, however, the results have been less than satisfactory. Mesenchymal stem cells within the stromal-vascular fraction of subcutaneous adipose tissue, adipose-derived stem cells (ADSCs), display multi-lineage developmental plasticity and secrete various growth factors that control and manage the damaged neighboring cells. Recently, the production and secretion of growth factors has been reported as an essential function of ADSCs, and diverse regenerative effects of ADSCs have been demonstrated in the skin. For example, conditioned medium from ADSCs (ADSC-CM) stimulated both collagen synthesis and migration of dermal fibroblasts, which improved the wrinkling and accelerated wound healing in animal models. ADSC-CM also inhibited melanogenesis in B16 melanoma cells, and protected dermal fibroblasts from oxidative stress induced by chemicals and UVB irradiation. Therefore, ADSCs and soluble factors show promise for the treatment of photoaging, and this review introduces recent research developments of the ADSCs and ADSC-derived secretory factors regarding this issue.

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalArchives of Dermatological Research
Volume301
Issue number5
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Stem Cells
Skin
Intercellular Signaling Peptides and Proteins
Fibroblasts
Experimental Melanomas
Stem Cell Factor
Subcutaneous Fat
Elasticity
Pigmentation
Conditioned Culture Medium
Mesenchymal Stromal Cells
Wound Healing
Blood Vessels
Oxidative Stress
Collagen
Animal Models
Research

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

@article{ac7a13d1f7f3434d941c0b6d70c476d9,
title = "Protective role of adipose-derived stem cells and their soluble factors in photoaging",
abstract = "As individuals age, the skin undergoes changes, such as irregular pigmentation, thinning and loss of elasticity, that are due to both genetic and environmental factors. These changes may worsen, progressing to precancerous and cancerous diseases. Various medical treatments and topical cosmeceuticals have been used to treat some symptoms of photoaging, however, the results have been less than satisfactory. Mesenchymal stem cells within the stromal-vascular fraction of subcutaneous adipose tissue, adipose-derived stem cells (ADSCs), display multi-lineage developmental plasticity and secrete various growth factors that control and manage the damaged neighboring cells. Recently, the production and secretion of growth factors has been reported as an essential function of ADSCs, and diverse regenerative effects of ADSCs have been demonstrated in the skin. For example, conditioned medium from ADSCs (ADSC-CM) stimulated both collagen synthesis and migration of dermal fibroblasts, which improved the wrinkling and accelerated wound healing in animal models. ADSC-CM also inhibited melanogenesis in B16 melanoma cells, and protected dermal fibroblasts from oxidative stress induced by chemicals and UVB irradiation. Therefore, ADSCs and soluble factors show promise for the treatment of photoaging, and this review introduces recent research developments of the ADSCs and ADSC-derived secretory factors regarding this issue.",
author = "Kim, {Won Serk} and Park, {Byung Soon} and Sung, {Jong Hyuk}",
year = "2009",
month = "6",
day = "1",
doi = "10.1007/s00403-009-0951-9",
language = "English",
volume = "301",
pages = "329--336",
journal = "Archives of Dermatological Research",
issn = "0340-3696",
publisher = "Springer Verlag",
number = "5",

}

Protective role of adipose-derived stem cells and their soluble factors in photoaging. / Kim, Won Serk; Park, Byung Soon; Sung, Jong Hyuk.

In: Archives of Dermatological Research, Vol. 301, No. 5, 01.06.2009, p. 329-336.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Protective role of adipose-derived stem cells and their soluble factors in photoaging

AU - Kim, Won Serk

AU - Park, Byung Soon

AU - Sung, Jong Hyuk

PY - 2009/6/1

Y1 - 2009/6/1

N2 - As individuals age, the skin undergoes changes, such as irregular pigmentation, thinning and loss of elasticity, that are due to both genetic and environmental factors. These changes may worsen, progressing to precancerous and cancerous diseases. Various medical treatments and topical cosmeceuticals have been used to treat some symptoms of photoaging, however, the results have been less than satisfactory. Mesenchymal stem cells within the stromal-vascular fraction of subcutaneous adipose tissue, adipose-derived stem cells (ADSCs), display multi-lineage developmental plasticity and secrete various growth factors that control and manage the damaged neighboring cells. Recently, the production and secretion of growth factors has been reported as an essential function of ADSCs, and diverse regenerative effects of ADSCs have been demonstrated in the skin. For example, conditioned medium from ADSCs (ADSC-CM) stimulated both collagen synthesis and migration of dermal fibroblasts, which improved the wrinkling and accelerated wound healing in animal models. ADSC-CM also inhibited melanogenesis in B16 melanoma cells, and protected dermal fibroblasts from oxidative stress induced by chemicals and UVB irradiation. Therefore, ADSCs and soluble factors show promise for the treatment of photoaging, and this review introduces recent research developments of the ADSCs and ADSC-derived secretory factors regarding this issue.

AB - As individuals age, the skin undergoes changes, such as irregular pigmentation, thinning and loss of elasticity, that are due to both genetic and environmental factors. These changes may worsen, progressing to precancerous and cancerous diseases. Various medical treatments and topical cosmeceuticals have been used to treat some symptoms of photoaging, however, the results have been less than satisfactory. Mesenchymal stem cells within the stromal-vascular fraction of subcutaneous adipose tissue, adipose-derived stem cells (ADSCs), display multi-lineage developmental plasticity and secrete various growth factors that control and manage the damaged neighboring cells. Recently, the production and secretion of growth factors has been reported as an essential function of ADSCs, and diverse regenerative effects of ADSCs have been demonstrated in the skin. For example, conditioned medium from ADSCs (ADSC-CM) stimulated both collagen synthesis and migration of dermal fibroblasts, which improved the wrinkling and accelerated wound healing in animal models. ADSC-CM also inhibited melanogenesis in B16 melanoma cells, and protected dermal fibroblasts from oxidative stress induced by chemicals and UVB irradiation. Therefore, ADSCs and soluble factors show promise for the treatment of photoaging, and this review introduces recent research developments of the ADSCs and ADSC-derived secretory factors regarding this issue.

UR - http://www.scopus.com/inward/record.url?scp=67651163446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651163446&partnerID=8YFLogxK

U2 - 10.1007/s00403-009-0951-9

DO - 10.1007/s00403-009-0951-9

M3 - Short survey

C2 - 19396609

AN - SCOPUS:67651163446

VL - 301

SP - 329

EP - 336

JO - Archives of Dermatological Research

JF - Archives of Dermatological Research

SN - 0340-3696

IS - 5

ER -