Protein folding using fragment assembly and physical energy function

Seung Yeon Kim, Weontae Lee, Julian Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We perform a systematic study of the effects of sequence-independent backbone interactions and sequence-dependent side-chain interactions on protein folding using fragment assembly and physical energy function. Structures for ten proteins belonging to various structural classes are predicted only with Lennard-Jones interaction between backbone atoms. We find nativelike structures for Β proteins, suggesting that for proteins in this class, the global tertiary structures can be determined mainly by sequence-independent backbone interactions. On the other hand, for α proteins, nonlocal hydrophobic side-chain interaction is also required to obtain nativelike structures.

Original languageEnglish
Article number194908
JournalJournal of Chemical Physics
Volume125
Issue number19
DOIs
Publication statusPublished - 2006 Dec 12

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Protein folding
folding
assembly
fragments
proteins
Proteins
interactions
energy
Atoms
atoms

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Cite this

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Protein folding using fragment assembly and physical energy function. / Kim, Seung Yeon; Lee, Weontae; Lee, Julian.

In: Journal of Chemical Physics, Vol. 125, No. 19, 194908, 12.12.2006.

Research output: Contribution to journalArticle

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