Protein interaction networks from yeast to human

Peer Bork, Lars J. Jensen, Christian Von Mering, Arun K. Ramani, Insuk Lee, Edward M. Marcotte

Research output: Contribution to journalReview article

263 Citations (Scopus)

Abstract

Protein interaction networks summarize large amounts of protein-protein interaction data, both from individual, small-scale experiments and from automated high-throughput screens. The past year has seen a flood of new experimental data, especially on metazoans, as well as an increasing number of analyses designed to reveal aspects of network topology, modularity and evolution. As only minimal progress has been made in mapping the human proteome using high-throughput screens, the transfer of interaction information within and across species has become increasingly important. With more and more heterogeneous raw data becoming available, proper data integration and quality control have become essential for reliable protein network reconstruction, and will be especially important for reconstructing the human protein interaction network.

Original languageEnglish
Pages (from-to)292-299
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume14
Issue number3
DOIs
Publication statusPublished - 2004 Jun

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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    Bork, P., Jensen, L. J., Von Mering, C., Ramani, A. K., Lee, I., & Marcotte, E. M. (2004). Protein interaction networks from yeast to human. Current Opinion in Structural Biology, 14(3), 292-299. https://doi.org/10.1016/j.sbi.2004.05.003