Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia

Ji Won Lee, Jeong Ae Park, Se Hee Kim, Ji Hae Seo, Kyung Joon Lim, Joo Won Jeong, Chul Ho Jeong, Kwang Hoon Chun, Seung Ki Lee, Young Guen Kwon, Kyu Won Kim

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Abstract

Hypoxia is a state of deficiency of available oxygen in the blood and tissues, and it occurs during several pathophysiological processes, including tumorigenesis. Under hypoxia, hypoxia-inducible factor-1 (HIF-1) plays an essential role in cellular oxygen homeostasis. In the present article protein kinase C-δ (PKC-δ) is activated by hypoxia, increases the protein stability and transcriptional activity of HIF-1α in human cervical adenocarcinoma cells. Moreover, the knockdown of PKC-δ inhibited vascular endothelial growth factor expression and angiogenic activity under hypoxia. These effects were completely reversed by PKC-δ overexpression following the knockdown of PKC-δ. Collectively, these findings demonstrate the role of PKC-δ as a new regulator of hypoxia-induced angiogenesis.

Original languageEnglish
Pages (from-to)1476-1481
Number of pages6
JournalCancer Science
Volume98
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lee, J. W., Park, J. A., Kim, S. H., Seo, J. H., Lim, K. J., Jeong, J. W., Jeong, C. H., Chun, K. H., Lee, S. K., Kwon, Y. G., & Kim, K. W. (2007). Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia. Cancer Science, 98(9), 1476-1481. https://doi.org/10.1111/j.1349-7006.2007.00535.x