Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia

Ji Won Lee, Jeong Ae Park, Se Hee Kim, Ji Hae Seo, Kyung Joon Lim, Joo Won Jeong, Chul Ho Jeong, Kwang Hoon Chun, Seung Ki Lee, Young-Guen Kwon, Kyu Won Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Hypoxia is a state of deficiency of available oxygen in the blood and tissues, and it occurs during several pathophysiological processes, including tumorigenesis. Under hypoxia, hypoxia-inducible factor-1 (HIF-1) plays an essential role in cellular oxygen homeostasis. In the present article protein kinase C-δ (PKC-δ) is activated by hypoxia, increases the protein stability and transcriptional activity of HIF-1α in human cervical adenocarcinoma cells. Moreover, the knockdown of PKC-δ inhibited vascular endothelial growth factor expression and angiogenic activity under hypoxia. These effects were completely reversed by PKC-δ overexpression following the knockdown of PKC-δ. Collectively, these findings demonstrate the role of PKC-δ as a new regulator of hypoxia-induced angiogenesis.

Original languageEnglish
Pages (from-to)1476-1481
Number of pages6
JournalCancer Science
Volume98
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

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Hypoxia-Inducible Factor 1
Protein Kinase C
Protein Stability
Vascular Endothelial Growth Factor A
Hypoxia
Carcinogenesis
Adenocarcinoma
Homeostasis
Oxygen

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lee, J. W., Park, J. A., Kim, S. H., Seo, J. H., Lim, K. J., Jeong, J. W., ... Kim, K. W. (2007). Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia. Cancer Science, 98(9), 1476-1481. https://doi.org/10.1111/j.1349-7006.2007.00535.x
Lee, Ji Won ; Park, Jeong Ae ; Kim, Se Hee ; Seo, Ji Hae ; Lim, Kyung Joon ; Jeong, Joo Won ; Jeong, Chul Ho ; Chun, Kwang Hoon ; Lee, Seung Ki ; Kwon, Young-Guen ; Kim, Kyu Won. / Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia. In: Cancer Science. 2007 ; Vol. 98, No. 9. pp. 1476-1481.
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Lee, JW, Park, JA, Kim, SH, Seo, JH, Lim, KJ, Jeong, JW, Jeong, CH, Chun, KH, Lee, SK, Kwon, Y-G & Kim, KW 2007, 'Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia', Cancer Science, vol. 98, no. 9, pp. 1476-1481. https://doi.org/10.1111/j.1349-7006.2007.00535.x

Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia. / Lee, Ji Won; Park, Jeong Ae; Kim, Se Hee; Seo, Ji Hae; Lim, Kyung Joon; Jeong, Joo Won; Jeong, Chul Ho; Chun, Kwang Hoon; Lee, Seung Ki; Kwon, Young-Guen; Kim, Kyu Won.

In: Cancer Science, Vol. 98, No. 9, 01.09.2007, p. 1476-1481.

Research output: Contribution to journalArticle

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AU - Lee, Ji Won

AU - Park, Jeong Ae

AU - Kim, Se Hee

AU - Seo, Ji Hae

AU - Lim, Kyung Joon

AU - Jeong, Joo Won

AU - Jeong, Chul Ho

AU - Chun, Kwang Hoon

AU - Lee, Seung Ki

AU - Kwon, Young-Guen

AU - Kim, Kyu Won

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AB - Hypoxia is a state of deficiency of available oxygen in the blood and tissues, and it occurs during several pathophysiological processes, including tumorigenesis. Under hypoxia, hypoxia-inducible factor-1 (HIF-1) plays an essential role in cellular oxygen homeostasis. In the present article protein kinase C-δ (PKC-δ) is activated by hypoxia, increases the protein stability and transcriptional activity of HIF-1α in human cervical adenocarcinoma cells. Moreover, the knockdown of PKC-δ inhibited vascular endothelial growth factor expression and angiogenic activity under hypoxia. These effects were completely reversed by PKC-δ overexpression following the knockdown of PKC-δ. Collectively, these findings demonstrate the role of PKC-δ as a new regulator of hypoxia-induced angiogenesis.

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