Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia

Ji Won Lee; Jeong Ae Park; Se Hee Kim; Ji Hae Seo; Kyung Joon Lim; Joo Won Jeong; Chul Ho Jeong; Kwang Hoon Chun; Seung Ki Lee; Young Guen Kwon; Kyu Won Kim

doi:10.1111/j.1349-7006.2007.00535.x

Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia

Ji Won Lee, Jeong Ae Park, Se Hee Kim, Ji Hae Seo, Kyung Joon Lim, Joo Won Jeong, Chul Ho Jeong, Kwang Hoon Chun, Seung Ki Lee, Young Guen Kwon, Kyu Won Kim

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Hypoxia is a state of deficiency of available oxygen in the blood and tissues, and it occurs during several pathophysiological processes, including tumorigenesis. Under hypoxia, hypoxia-inducible factor-1 (HIF-1) plays an essential role in cellular oxygen homeostasis. In the present article protein kinase C-δ (PKC-δ) is activated by hypoxia, increases the protein stability and transcriptional activity of HIF-1α in human cervical adenocarcinoma cells. Moreover, the knockdown of PKC-δ inhibited vascular endothelial growth factor expression and angiogenic activity under hypoxia. These effects were completely reversed by PKC-δ overexpression following the knockdown of PKC-δ. Collectively, these findings demonstrate the role of PKC-δ as a new regulator of hypoxia-induced angiogenesis.

Original language	English
Pages (from-to)	1476-1481
Number of pages	6
Journal	Cancer Science
Volume	98
Issue number	9
DOIs	https://doi.org/10.1111/j.1349-7006.2007.00535.x
Publication status	Published - 2007 Sept

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.2007.00535.x

Cite this

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title = "Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia",

abstract = "Hypoxia is a state of deficiency of available oxygen in the blood and tissues, and it occurs during several pathophysiological processes, including tumorigenesis. Under hypoxia, hypoxia-inducible factor-1 (HIF-1) plays an essential role in cellular oxygen homeostasis. In the present article protein kinase C-δ (PKC-δ) is activated by hypoxia, increases the protein stability and transcriptional activity of HIF-1α in human cervical adenocarcinoma cells. Moreover, the knockdown of PKC-δ inhibited vascular endothelial growth factor expression and angiogenic activity under hypoxia. These effects were completely reversed by PKC-δ overexpression following the knockdown of PKC-δ. Collectively, these findings demonstrate the role of PKC-δ as a new regulator of hypoxia-induced angiogenesis.",

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language = "English",

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journal = "Cancer Science",

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T1 - Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia

AU - Lee, Ji Won

AU - Park, Jeong Ae

AU - Kim, Se Hee

AU - Seo, Ji Hae

AU - Lim, Kyung Joon

AU - Jeong, Joo Won

AU - Jeong, Chul Ho

AU - Chun, Kwang Hoon

AU - Lee, Seung Ki

AU - Kwon, Young Guen

AU - Kim, Kyu Won

PY - 2007/9

Y1 - 2007/9

N2 - Hypoxia is a state of deficiency of available oxygen in the blood and tissues, and it occurs during several pathophysiological processes, including tumorigenesis. Under hypoxia, hypoxia-inducible factor-1 (HIF-1) plays an essential role in cellular oxygen homeostasis. In the present article protein kinase C-δ (PKC-δ) is activated by hypoxia, increases the protein stability and transcriptional activity of HIF-1α in human cervical adenocarcinoma cells. Moreover, the knockdown of PKC-δ inhibited vascular endothelial growth factor expression and angiogenic activity under hypoxia. These effects were completely reversed by PKC-δ overexpression following the knockdown of PKC-δ. Collectively, these findings demonstrate the role of PKC-δ as a new regulator of hypoxia-induced angiogenesis.

AB - Hypoxia is a state of deficiency of available oxygen in the blood and tissues, and it occurs during several pathophysiological processes, including tumorigenesis. Under hypoxia, hypoxia-inducible factor-1 (HIF-1) plays an essential role in cellular oxygen homeostasis. In the present article protein kinase C-δ (PKC-δ) is activated by hypoxia, increases the protein stability and transcriptional activity of HIF-1α in human cervical adenocarcinoma cells. Moreover, the knockdown of PKC-δ inhibited vascular endothelial growth factor expression and angiogenic activity under hypoxia. These effects were completely reversed by PKC-δ overexpression following the knockdown of PKC-δ. Collectively, these findings demonstrate the role of PKC-δ as a new regulator of hypoxia-induced angiogenesis.

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Protein kinase C-δ regulates the stability of hypoxia-inducible factor-1α under hypoxia

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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