Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway

Sujin Park, Si Hyoung Park, Ju Yuel Baek, Ye Jin Jy, Kwan Soo Kim, Jürgen Roth, Jin Won Cho, Kwang Min Choe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Modification of nuclear and cytosolic proteins by O-linked N-acetylglucosamine (O-GlcNAcylation) is ubiquitous in cells. The in vivo function of the protein O-GlcNAcylation, however, is not well understood. Here, we manipulated the cellular O-GlcNAcylation level in Drosophila and found that it promotes developmental growth by enhancing insulin signaling. This increase in growth is due mainly to cell growth and not to cell proliferation. Our data suggest that the increase in the insulin signaling activity is mediated, at least in part, through O-GlcNAcylation of Akt. These results indicate that O-GlcNAcylation is one of the crucial mechanisms involved in control of insulin signaling during Drosophila development.

Original languageEnglish
Pages (from-to)3377-3384
Number of pages8
JournalCellular and Molecular Life Sciences
Volume68
Issue number20
DOIs
Publication statusPublished - 2011 Oct 1

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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