PROTEKT 1999-2000: A multicentre study of the antibiotic susceptibility of respiratory tract pathogens in Hong Kong, Japan and South Korea

Matsuhisa Inoue, Nam Yong Lee, Seto Wing Hong, Kyungwon Lee, David Felmingham

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A multicentre surveillance study performed in the Far East during 1999-2000 investigated the in vitro activity of >20 antibacterials against common respiratory pathogens. In Hong Kong, Japan, and South Korea, 57.1, 44.5 and 71.5% Streptococcus pneumoniae were penicillin-resistant and 71.4, 77.9 and 87.6% were erythromycin-resistant, respectively. Overall, >90% of penicillin-resistant strains were also macrolide-resistant. All strains were susceptible to telithromycin. Fluoroquinolone-resistant isolates in Japan (1.3%), Hong Kong (14.3%) and South Korea (2.9%) were mostly co-resistant to penicillin, macrolides and tetracycline. Beta-lactamase production by Haemophilus influenzae isolates was 8.5% in Japan, 17.1% in Hong Kong and 64.7% in strains from South Korea. A single (0.27%) BLNAR isolate was obtained in Japan. There was no fluoroquinolone resistance. Moraxella catarrhalis was inhibited by telithromycin at ≤0.5mg/l and remained susceptible to macrolides, fluoroquinolones and amoxicillin-clavulanate. Resistance to antibacterials, particularly penicillin and macrolides, has reached high but stable levels in the Far East and the presence of multiply-resistant pneumococci is well established.

Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalInternational Journal of Antimicrobial Agents
Issue number1
Publication statusPublished - 2004 Jan

Bibliographical note

Funding Information:
We gratefully acknowledge the contribution of the following investigators: Prof. M. Kaku, Tohoku University, Sendai; Prof. J. Igari, Juntendo University, Tokyo; Prof. K. Yamaguchi, Toho University, Tokyo; Prof. S. Kohno, Nagasaki University, Nagasaki; and Dr. K. Yamanaka, Otemae Hospital, Osaka. We also gratefully acknowledge the contribution of the scientific staff of GR Micro Ltd., London, UK. Data analysis was undertaken by Micron Research Ltd., Upwell, Cambs, UK and the PROTEKT surveillance survey is funded by Aventis.

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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