Proteome analysis of adrenal cortical tumors

Hye Min Kim, Yu Kyung Lee, Ja Seung Koo

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Introduction: Adrenal tumor is a relatively common tumor. The discrimination between adrenal cortical adenoma (ACA) and adrenal cortical carcinoma (ACC) is crucial as these two diseases have distinct prognosis. ACA is a benign tumor curable by surgical excision, while the prognosis of ACC is extremely poor, with a 5-year mortality of 75–90%. Therefore, previous proteomic studies focused on markers allowing the differentiation between ACA and ACC. Areas covered: Several proteomic approaches based on the analysis of various samples such as human tissues, urine, and cell lines. In this review, we focused on proteomic studies performed to improve adrenal tumor diagnosis and identify ACC therapeutic targets. Expert commentary: The rapid development of cancer genomics provided a lot of information, which affects functional proteomics. In practice, differentially expressed proteins between ACA and ACC have been suggested in several proteomic studies and had a biologic implication in ACC.

Original languageEnglish
Pages (from-to)747-755
Number of pages9
JournalExpert Review of Proteomics
Volume13
Issue number8
DOIs
Publication statusPublished - 2016 Aug 2

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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