Proto-oncogene PML enhances antigen presentation by MHC class I molecules in human lung cancer cells

Sook Kyung Chang, Boyoun Park, Jinwook Shin, Jin Hyun Ahn, Ik Hwan Kim, Kwangseog Ahn

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Deficient expression of the mouse proto-oncogene PML is associated with tumor immune evasion, occurring through down-regulated expression of genes involved in antigen processing and presentation. We investigated whether the defective antigen presentation found in human lung cancer cells could be restored by the human homolog of PML. PML induced the expression of MHC class I heavy chain and β2-microglobulin at the level of transcription, thereby restoring defective antigen presentation resolved in some, but not all, lung cancer cell lines. Furthermore, the capacity of PML to restore antigen presentation required its targeting into nuclear bodies. These findings might have important application in the development of antitumor immunotherapeutic strategies.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalMolecules and cells
Volume14
Issue number1
Publication statusPublished - 2002 Aug

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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    Chang, S. K., Park, B., Shin, J., Ahn, J. H., Kim, I. H., & Ahn, K. (2002). Proto-oncogene PML enhances antigen presentation by MHC class I molecules in human lung cancer cells. Molecules and cells, 14(1), 130-135.