Proton magnetic resonance spectroscopy of musculoskeletal lesions at 3 T with metabolite quantification

Chan Wha Lee, Joo Hyuk Lee, Dae Hong Kim, Hye Sook Min, Byung Kiu Park, Hwan Sung Cho, Hyun Guy Kang, Jin Suck Suh, Shigeru Ehara

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate whether proton MR spectroscopy (MRS) at 3 T with metabolite quantification is helpful for characterizing musculoskeletal lesions and to reveal whether the concentration of choline is correlated with the pathologic degree of malignancy. Material and methods: Three-tesla MR images and proton MRS data from 27 consecutive patients with surgically proven musculoskeletal lesions were retrospectively analyzed. We analyzed the presence of choline peaks of malignant tumors according to the degree of malignancies, and we compared them with those of benign lesions. The concentrations of choline calculated by means of the linear combination of model spectra were also compared with respect to the degree of malignancy in each group. Results: The proton MRS had an overall sensitivity of 68.4%, specificity of 87.5%, positive predictive value of 92.3%, and negative predictive value of 53.8% for the detection of choline compounds. The positive detection rate for choline compounds in the primary malignancy group (53.8%) was lower than that of the metastasis group (100%). All false-negative results were shown in the Grade 1 primary malignancy group. There was no difference in the concentration of choline compounds with respect to the pathologic degree of differentiation. Conclusion: MR spectroscopy at 3 T with metabolite quantification is a helpful method that shows high specificity (87.5%) in characterizing musculoskeletal lesions, even though its sensitivity (68.4%) is relatively low. Grade 1 primary malignancies of bone and soft tissue tumor have a high potential for producing false-negative results.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalClinical Imaging
Volume34
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

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Choline
Neoplasms
Magnetic Resonance Spectroscopy
Protons
Proton Magnetic Resonance Spectroscopy
Linear Models
Neoplasm Metastasis
Bone and Bones
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lee, C. W., Lee, J. H., Kim, D. H., Min, H. S., Park, B. K., Cho, H. S., ... Ehara, S. (2010). Proton magnetic resonance spectroscopy of musculoskeletal lesions at 3 T with metabolite quantification. Clinical Imaging, 34(1), 47-52. https://doi.org/10.1016/j.clinimag.2009.03.013
Lee, Chan Wha ; Lee, Joo Hyuk ; Kim, Dae Hong ; Min, Hye Sook ; Park, Byung Kiu ; Cho, Hwan Sung ; Kang, Hyun Guy ; Suh, Jin Suck ; Ehara, Shigeru. / Proton magnetic resonance spectroscopy of musculoskeletal lesions at 3 T with metabolite quantification. In: Clinical Imaging. 2010 ; Vol. 34, No. 1. pp. 47-52.
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abstract = "Purpose: To evaluate whether proton MR spectroscopy (MRS) at 3 T with metabolite quantification is helpful for characterizing musculoskeletal lesions and to reveal whether the concentration of choline is correlated with the pathologic degree of malignancy. Material and methods: Three-tesla MR images and proton MRS data from 27 consecutive patients with surgically proven musculoskeletal lesions were retrospectively analyzed. We analyzed the presence of choline peaks of malignant tumors according to the degree of malignancies, and we compared them with those of benign lesions. The concentrations of choline calculated by means of the linear combination of model spectra were also compared with respect to the degree of malignancy in each group. Results: The proton MRS had an overall sensitivity of 68.4{\%}, specificity of 87.5{\%}, positive predictive value of 92.3{\%}, and negative predictive value of 53.8{\%} for the detection of choline compounds. The positive detection rate for choline compounds in the primary malignancy group (53.8{\%}) was lower than that of the metastasis group (100{\%}). All false-negative results were shown in the Grade 1 primary malignancy group. There was no difference in the concentration of choline compounds with respect to the pathologic degree of differentiation. Conclusion: MR spectroscopy at 3 T with metabolite quantification is a helpful method that shows high specificity (87.5{\%}) in characterizing musculoskeletal lesions, even though its sensitivity (68.4{\%}) is relatively low. Grade 1 primary malignancies of bone and soft tissue tumor have a high potential for producing false-negative results.",
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Proton magnetic resonance spectroscopy of musculoskeletal lesions at 3 T with metabolite quantification. / Lee, Chan Wha; Lee, Joo Hyuk; Kim, Dae Hong; Min, Hye Sook; Park, Byung Kiu; Cho, Hwan Sung; Kang, Hyun Guy; Suh, Jin Suck; Ehara, Shigeru.

In: Clinical Imaging, Vol. 34, No. 1, 01.01.2010, p. 47-52.

Research output: Contribution to journalArticle

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