Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro

Joong Sup Shim, Hyi Seung Lee, Jongheon Shin, Ho Jeong Kwon

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Psammaplin A (PsA) is a phenolic natural product isolated from a marine sponge, which showed a potent cytotoxicity against several cancer cell lines. In present study, PsA was found to inhibit mammalian aminopeptidase N (APN) that plays a key role in tumor cell invasion and angiogenesis. PsA inhibited the APN activity with an IC50 of 18 μM in a non-competitive manner. Moreover, PsA potently inhibited the proliferation of several cancer and endothelial cells. Interestingly, the anti-proliferative effect of PsA was dependent on the cellular amount of APN expression. Finally, PsA suppressed the invasion and tube formation of endothelial cells stimulated by basic fibroblast growth factor. These data demonstrate that PsA is a new inhibitor of APN and can be developed as a novel anti-angiogenic agent.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalCancer Letters
Volume203
Issue number2
DOIs
Publication statusPublished - 2004 Jan

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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