PTEN methylation dependent sinonasal mucosal melanoma

Sang Hee Lee, MiRyung Roh, Beodeul Kang, Kyu Hyun Park, Soo Hee Kim, Sang Eun Lee, SunYoung Rha

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.

Original languageEnglish
Pages (from-to)853-858
Number of pages6
JournalCancer Research and Treatment
Volume48
Issue number2
DOIs
Publication statusPublished - 2016 Apr 1

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Methylation
Melanoma
Epigenomics
Phosphatidylinositol 3-Kinase
CpG Islands
Mitogen-Activated Protein Kinase Kinases
Carcinogenesis
Neoplasm Metastasis
Bone and Bones
Mutation
Liver
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lee, Sang Hee ; Roh, MiRyung ; Kang, Beodeul ; Park, Kyu Hyun ; Kim, Soo Hee ; Lee, Sang Eun ; Rha, SunYoung. / PTEN methylation dependent sinonasal mucosal melanoma. In: Cancer Research and Treatment. 2016 ; Vol. 48, No. 2. pp. 853-858.
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abstract = "Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.",
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PTEN methylation dependent sinonasal mucosal melanoma. / Lee, Sang Hee; Roh, MiRyung; Kang, Beodeul; Park, Kyu Hyun; Kim, Soo Hee; Lee, Sang Eun; Rha, SunYoung.

In: Cancer Research and Treatment, Vol. 48, No. 2, 01.04.2016, p. 853-858.

Research output: Contribution to journalArticle

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AB - Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.

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