Abstract
Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.
| Original language | English |
|---|---|
| Pages (from-to) | 853-858 |
| Number of pages | 6 |
| Journal | Cancer Research and Treatment |
| Volume | 48 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2016 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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PTEN methylation dependent sinonasal mucosal melanoma. / Lee, Sang Hee; Roh, MiRyung; Kang, Beodeul; Park, Kyu Hyun; Kim, Soo Hee; Lee, Sang Eun; Rha, SunYoung.
In: Cancer Research and Treatment, Vol. 48, No. 2, 01.04.2016, p. 853-858.Research output: Contribution to journal › Article
TY - JOUR
T1 - PTEN methylation dependent sinonasal mucosal melanoma
AU - Lee, Sang Hee
AU - Roh, MiRyung
AU - Kang, Beodeul
AU - Park, Kyu Hyun
AU - Kim, Soo Hee
AU - Lee, Sang Eun
AU - Rha, SunYoung
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.
AB - Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.
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U2 - 10.4143/crt.2014.356
DO - 10.4143/crt.2014.356
M3 - Article
VL - 48
SP - 853
EP - 858
JO - Cancer Research and Treatment
JF - Cancer Research and Treatment
SN - 1598-2998
IS - 2
ER -