PTEN methylation dependent sinonasal mucosal melanoma

Sang Hee Lee; Mi Ryung Roh; Beodeul Kang; Kyu Hyun Park; Soo Hee Kim; Sang Eun Lee; Sun Young Rha

doi:10.4143/crt.2014.356

PTEN methylation dependent sinonasal mucosal melanoma

Sang Hee Lee, Mi Ryung Roh, Beodeul Kang, Kyu Hyun Park, Soo Hee Kim, Sang Eun Lee, Sun Young Rha

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.

Original language	English
Pages (from-to)	853-858
Number of pages	6
Journal	Cancer Research and Treatment
Volume	48
Issue number	2
DOIs	https://doi.org/10.4143/crt.2014.356
Publication status	Published - 2016 Apr 1

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Education, Science, and Technology (2011-0022376).

Publisher Copyright:
© 2016 by the Korean Cancer Association.

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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title = "PTEN methylation dependent sinonasal mucosal melanoma",

abstract = "Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.",

author = "Lee, {Sang Hee} and Roh, {Mi Ryung} and Beodeul Kang and Park, {Kyu Hyun} and Kim, {Soo Hee} and Lee, {Sang Eun} and Rha, {Sun Young}",

note = "Funding Information: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Education, Science, and Technology (2011-0022376). Publisher Copyright: {\textcopyright} 2016 by the Korean Cancer Association.",

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doi = "10.4143/crt.2014.356",

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T1 - PTEN methylation dependent sinonasal mucosal melanoma

AU - Lee, Sang Hee

AU - Roh, Mi Ryung

AU - Kang, Beodeul

AU - Park, Kyu Hyun

AU - Kim, Soo Hee

AU - Lee, Sang Eun

AU - Rha, Sun Young

N1 - Funding Information: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Education, Science, and Technology (2011-0022376). Publisher Copyright: © 2016 by the Korean Cancer Association.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.

AB - Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the phosphatidylinositol 3-kinase-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, c-Kit, and PTEN were negative; however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.

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PTEN methylation dependent sinonasal mucosal melanoma

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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