Pulmonary langerhans cell histiocytosis in an adult male presenting with central diabetes insipidus and diabetes mellitus

A case report

Yeun Seoung Choi, Jung Soo Lim, Woocheol Kwon, Soon Hee Jung, Il Hwan Park, Myoung Kyu Lee, Won Yeon Lee, Suk Joong Yong, Seok Jeong Lee, Ye Ryung Jung, Jiwon Choi, Ji Sun Choi, Joon Taek Jeong, Jin Sae Yoo, Sangha Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalTuberculosis and Respiratory Diseases
Volume78
Issue number4
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

Neurogenic Diabetes Insipidus
Langerhans Cell Histiocytosis
Diabetes Mellitus
Lung
Polydipsia
Water Deprivation
Video-Assisted Thoracic Surgery
Hyperphagia
Diabetes Insipidus
Cough
Dyspnea
Type 2 Diabetes Mellitus
Smoking
Magnetic Resonance Imaging
Biopsy

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Choi, Yeun Seoung ; Lim, Jung Soo ; Kwon, Woocheol ; Jung, Soon Hee ; Park, Il Hwan ; Lee, Myoung Kyu ; Lee, Won Yeon ; Yong, Suk Joong ; Lee, Seok Jeong ; Jung, Ye Ryung ; Choi, Jiwon ; Choi, Ji Sun ; Jeong, Joon Taek ; Yoo, Jin Sae ; Kim, Sangha. / Pulmonary langerhans cell histiocytosis in an adult male presenting with central diabetes insipidus and diabetes mellitus : A case report. In: Tuberculosis and Respiratory Diseases. 2015 ; Vol. 78, No. 4. pp. 463-468.
@article{0bdb0b5c5c9d4baa8bf55bf9fbb246b9,
title = "Pulmonary langerhans cell histiocytosis in an adult male presenting with central diabetes insipidus and diabetes mellitus: A case report",
abstract = "Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.",
author = "Choi, {Yeun Seoung} and Lim, {Jung Soo} and Woocheol Kwon and Jung, {Soon Hee} and Park, {Il Hwan} and Lee, {Myoung Kyu} and Lee, {Won Yeon} and Yong, {Suk Joong} and Lee, {Seok Jeong} and Jung, {Ye Ryung} and Jiwon Choi and Choi, {Ji Sun} and Jeong, {Joon Taek} and Yoo, {Jin Sae} and Sangha Kim",
year = "2015",
month = "10",
day = "1",
doi = "10.4046/trd.2015.78.4.463",
language = "English",
volume = "78",
pages = "463--468",
journal = "Tuberculosis and Respiratory Diseases",
issn = "1738-3536",
publisher = "The Korean Academy of Tuberculosis and Respiratory Diseases",
number = "4",

}

Choi, YS, Lim, JS, Kwon, W, Jung, SH, Park, IH, Lee, MK, Lee, WY, Yong, SJ, Lee, SJ, Jung, YR, Choi, J, Choi, JS, Jeong, JT, Yoo, JS & Kim, S 2015, 'Pulmonary langerhans cell histiocytosis in an adult male presenting with central diabetes insipidus and diabetes mellitus: A case report', Tuberculosis and Respiratory Diseases, vol. 78, no. 4, pp. 463-468. https://doi.org/10.4046/trd.2015.78.4.463

Pulmonary langerhans cell histiocytosis in an adult male presenting with central diabetes insipidus and diabetes mellitus : A case report. / Choi, Yeun Seoung; Lim, Jung Soo; Kwon, Woocheol; Jung, Soon Hee; Park, Il Hwan; Lee, Myoung Kyu; Lee, Won Yeon; Yong, Suk Joong; Lee, Seok Jeong; Jung, Ye Ryung; Choi, Jiwon; Choi, Ji Sun; Jeong, Joon Taek; Yoo, Jin Sae; Kim, Sangha.

In: Tuberculosis and Respiratory Diseases, Vol. 78, No. 4, 01.10.2015, p. 463-468.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pulmonary langerhans cell histiocytosis in an adult male presenting with central diabetes insipidus and diabetes mellitus

T2 - A case report

AU - Choi, Yeun Seoung

AU - Lim, Jung Soo

AU - Kwon, Woocheol

AU - Jung, Soon Hee

AU - Park, Il Hwan

AU - Lee, Myoung Kyu

AU - Lee, Won Yeon

AU - Yong, Suk Joong

AU - Lee, Seok Jeong

AU - Jung, Ye Ryung

AU - Choi, Jiwon

AU - Choi, Ji Sun

AU - Jeong, Joon Taek

AU - Yoo, Jin Sae

AU - Kim, Sangha

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.

AB - Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.

UR - http://www.scopus.com/inward/record.url?scp=84953709530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953709530&partnerID=8YFLogxK

U2 - 10.4046/trd.2015.78.4.463

DO - 10.4046/trd.2015.78.4.463

M3 - Article

VL - 78

SP - 463

EP - 468

JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

SN - 1738-3536

IS - 4

ER -