Pustulotic arthro-osteitis improved with anti TNF-tf inhibitor

Hae Seok Park, Jong Hoon Kim, Hye Won Kim, Soo Chan Kim

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Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disorder characterized by inflammatory osteitis of the sternoclavicular joint and palmoplantar pustulosis. Here, we report a case of PAO that was successfully treated with a TNF-a inhibitor. A 45-year-old man presented with a 3-month history of pustular eruption on the palms and soles. Physical examination showed multiple erythematous papulopustules on the palms, back, and left shin, accompanied by sternoclavicular joint swelling and tenderness. Skin biopsy showed intraepidermal pustules filled with neutrophils on the palm. Bone scintigraphy revealed increased uptake in the bilateral sternoclavicular and other axial joints. Based on these findings, we made the diagnosis of PAO. Even after 6-month treatment of oral steroids and cyclosporine, skin manifestations insufficiently improved, so etanercept therapy was started. Complete clearance of skin lesions and joint pain were achieved after 3 months of etanercept therapy. (Korean J Dermatol 2019;57(7): 378-382).

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalKorean Journal of Dermatology
Issue number7
Publication statusPublished - 2019 Aug

Bibliographical note

Publisher Copyright:
© 2019 Korean Dermatological Association. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Dermatology


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