pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases

In Young Hwang, Jae Seok Roe, Ja Hwan Seol, Hwa Ryeon Kim, Eun Jung Cho, Hong Duk Youn

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The biological functions of Myc are to regulate cell growth, apoptosis, cell differentiation and stem-cell self-renewal. Abnormal accumulation of c-Myc is able to induce excessive proliferation of normal cells. von Hippel-Lindau protein (pVHL) is a key regulator of hypoxia-inducible factor1α (HIF1α), thus accumulation and hyperactivation of HIF1α is the most prominent feature of VHL-mutated renal cell carcinoma. Interestingly, the Myc pathway is reported to be activated in renal cell carcinoma even though the precise molecular mechanism still remains to be established. Here, we demonstrated that pVHL locates at the c-Myc promoter region through physical interaction with Myc. Furthermore, pVHL reinforces HDAC1/2 recruitment to the Myc promoter, which leads to the auto-suppression of Myc. Therefore, one possible mechanism of Myc auto-suppression by pVHL entails removing histone acetylation. Our study identifies a novel mechanism for pVHL-mediated negative regulation of c-Myc transcription.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalMolecules and cells
Volume33
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

Fingerprint

Histone Deacetylases
Renal Cell Carcinoma
Acetylation
Genetic Promoter Regions
Histones
Cell Differentiation
Cell Proliferation
Apoptosis
Growth
Proteins
Hypoxia
Cell Self Renewal

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Hwang, In Young ; Roe, Jae Seok ; Seol, Ja Hwan ; Kim, Hwa Ryeon ; Cho, Eun Jung ; Youn, Hong Duk. / pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases. In: Molecules and cells. 2012 ; Vol. 33, No. 2. pp. 195-201.
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pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases. / Hwang, In Young; Roe, Jae Seok; Seol, Ja Hwan; Kim, Hwa Ryeon; Cho, Eun Jung; Youn, Hong Duk.

In: Molecules and cells, Vol. 33, No. 2, 01.02.2012, p. 195-201.

Research output: Contribution to journalArticle

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AU - Seol, Ja Hwan

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AB - The biological functions of Myc are to regulate cell growth, apoptosis, cell differentiation and stem-cell self-renewal. Abnormal accumulation of c-Myc is able to induce excessive proliferation of normal cells. von Hippel-Lindau protein (pVHL) is a key regulator of hypoxia-inducible factor1α (HIF1α), thus accumulation and hyperactivation of HIF1α is the most prominent feature of VHL-mutated renal cell carcinoma. Interestingly, the Myc pathway is reported to be activated in renal cell carcinoma even though the precise molecular mechanism still remains to be established. Here, we demonstrated that pVHL locates at the c-Myc promoter region through physical interaction with Myc. Furthermore, pVHL reinforces HDAC1/2 recruitment to the Myc promoter, which leads to the auto-suppression of Myc. Therefore, one possible mechanism of Myc auto-suppression by pVHL entails removing histone acetylation. Our study identifies a novel mechanism for pVHL-mediated negative regulation of c-Myc transcription.

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