QRS prolongation in the prediction of clinical cardiac events in patients with acute heart failure

Analysis of data from the Korean acute heart failure registry

Korean Acute Heart Failure Registry

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: A prolonged QRS duration has been associated with an unfavorable prognosis in chronic compensated heart failure (HF). However, its predictive value during an admission for acute HF is limited, even in HF with a preserved ejection fraction (EF). The purpose of this study was to evaluate the prognostic utility of the QRS duration in acute HF. Methods: Analyses were performed using data from 1,489 patients with a 2-year follow-up. The patients were selected from the Korean Acute Heart Failure Registry and were divided into three groups according to QRS duration (≤80, 81-119 or ≥120 ms). The all-cause mortality and readmission for HF were assessed. Results: During the study period, 774 primary events occurred (359 deaths and 415 HF). The event frequencies were higher in patients with a prolonged QRS duration. The increased risk associated with the QRS duration was also demonstrated after adjustment for cardiac outcome variables. The prognostic significance of the QRS duration was demonstrated in patients with reduced EF but not in those with a preserved EF. Conclusions: A prolonged QRS duration could be a significant predictor of the 2-year cardiac outcome in patients with acute HF, particularly in those with a reduced EF.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalCardiology (Switzerland)
Volume125
Issue number2
DOIs
Publication statusPublished - 2013 Jan 1

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Registries
Heart Failure
Mortality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

@article{1937932eea3a44ee8a2412031045b148,
title = "QRS prolongation in the prediction of clinical cardiac events in patients with acute heart failure: Analysis of data from the Korean acute heart failure registry",
abstract = "Objectives: A prolonged QRS duration has been associated with an unfavorable prognosis in chronic compensated heart failure (HF). However, its predictive value during an admission for acute HF is limited, even in HF with a preserved ejection fraction (EF). The purpose of this study was to evaluate the prognostic utility of the QRS duration in acute HF. Methods: Analyses were performed using data from 1,489 patients with a 2-year follow-up. The patients were selected from the Korean Acute Heart Failure Registry and were divided into three groups according to QRS duration (≤80, 81-119 or ≥120 ms). The all-cause mortality and readmission for HF were assessed. Results: During the study period, 774 primary events occurred (359 deaths and 415 HF). The event frequencies were higher in patients with a prolonged QRS duration. The increased risk associated with the QRS duration was also demonstrated after adjustment for cardiac outcome variables. The prognostic significance of the QRS duration was demonstrated in patients with reduced EF but not in those with a preserved EF. Conclusions: A prolonged QRS duration could be a significant predictor of the 2-year cardiac outcome in patients with acute HF, particularly in those with a reduced EF.",
author = "{Korean Acute Heart Failure Registry} and Park, {Hyoung Seob} and Hyungseop Kim and Park, {Jae Hyeong} and Seongwoo Han and Byungsu Yoo and Shin, {Mi Seung} and Seong, {In Whan} and Youngkeun Ahn and seokmin kang and Kim, {Jae Joong} and Jeon, {Eun Seok} and Cho, {Myeong Chan} and Choi, {Dong Ju} and Chae, {Shung Chull} and Kim, {Yung Jo} and Seo, {Hong Seog} and Oh, {Byung Hee} and Lee, {Myung Mook} and Ryu, {Kyu Hyung}",
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QRS prolongation in the prediction of clinical cardiac events in patients with acute heart failure : Analysis of data from the Korean acute heart failure registry. / Korean Acute Heart Failure Registry.

In: Cardiology (Switzerland), Vol. 125, No. 2, 01.01.2013, p. 96-103.

Research output: Contribution to journalArticle

TY - JOUR

T1 - QRS prolongation in the prediction of clinical cardiac events in patients with acute heart failure

T2 - Analysis of data from the Korean acute heart failure registry

AU - Korean Acute Heart Failure Registry

AU - Park, Hyoung Seob

AU - Kim, Hyungseop

AU - Park, Jae Hyeong

AU - Han, Seongwoo

AU - Yoo, Byungsu

AU - Shin, Mi Seung

AU - Seong, In Whan

AU - Ahn, Youngkeun

AU - kang, seokmin

AU - Kim, Jae Joong

AU - Jeon, Eun Seok

AU - Cho, Myeong Chan

AU - Choi, Dong Ju

AU - Chae, Shung Chull

AU - Kim, Yung Jo

AU - Seo, Hong Seog

AU - Oh, Byung Hee

AU - Lee, Myung Mook

AU - Ryu, Kyu Hyung

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objectives: A prolonged QRS duration has been associated with an unfavorable prognosis in chronic compensated heart failure (HF). However, its predictive value during an admission for acute HF is limited, even in HF with a preserved ejection fraction (EF). The purpose of this study was to evaluate the prognostic utility of the QRS duration in acute HF. Methods: Analyses were performed using data from 1,489 patients with a 2-year follow-up. The patients were selected from the Korean Acute Heart Failure Registry and were divided into three groups according to QRS duration (≤80, 81-119 or ≥120 ms). The all-cause mortality and readmission for HF were assessed. Results: During the study period, 774 primary events occurred (359 deaths and 415 HF). The event frequencies were higher in patients with a prolonged QRS duration. The increased risk associated with the QRS duration was also demonstrated after adjustment for cardiac outcome variables. The prognostic significance of the QRS duration was demonstrated in patients with reduced EF but not in those with a preserved EF. Conclusions: A prolonged QRS duration could be a significant predictor of the 2-year cardiac outcome in patients with acute HF, particularly in those with a reduced EF.

AB - Objectives: A prolonged QRS duration has been associated with an unfavorable prognosis in chronic compensated heart failure (HF). However, its predictive value during an admission for acute HF is limited, even in HF with a preserved ejection fraction (EF). The purpose of this study was to evaluate the prognostic utility of the QRS duration in acute HF. Methods: Analyses were performed using data from 1,489 patients with a 2-year follow-up. The patients were selected from the Korean Acute Heart Failure Registry and were divided into three groups according to QRS duration (≤80, 81-119 or ≥120 ms). The all-cause mortality and readmission for HF were assessed. Results: During the study period, 774 primary events occurred (359 deaths and 415 HF). The event frequencies were higher in patients with a prolonged QRS duration. The increased risk associated with the QRS duration was also demonstrated after adjustment for cardiac outcome variables. The prognostic significance of the QRS duration was demonstrated in patients with reduced EF but not in those with a preserved EF. Conclusions: A prolonged QRS duration could be a significant predictor of the 2-year cardiac outcome in patients with acute HF, particularly in those with a reduced EF.

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DO - 10.1159/000348334

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JO - Cardiology

JF - Cardiology

SN - 0008-6312

IS - 2

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