Quantification of intracranial internal carotid artery calcification on brain unenhanced CT

Evaluation of its feasibility and assessment of the reliability of visual grading scales

Sung Soo Ahn, Hyo Suk Nam, Jihoe Heo, Young Dae Kim, Seung Koo Lee, Kyunghwa Han, Eung Yeop Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: Previous studies have evaluated intracranial internal carotid artery calcifications (ICACs) qualitatively using different visual grading scales, which could lead to inconsistent results. The purpose of this study was to evaluate the feasibility of ICAC volume measurement and to correlate the volume with visual grading scales. Methods: We included 49 patients (>50years) who underwent unenhanced cranial CT. Two observers evaluated four visual grading scales and measured ICAC volumes semi-automatically, and interobserver agreements were assessed. Differences in ICAC volume between visual grades of each scale were tested. The relationship between the visual grading and volume was assessed. Results: Interobserver agreements ranged from 0.841 to 0.901 for visual grading and 0.997 for volume measurement. Mean volumes were not significantly different between the visual grades (P > 0.05) except when comparing grade 4 with the other grades. The grades of each visual grading correlated well with ICAC volumes (Spearman's ρ = 0.849-0.881, P < 0.001). The relationship between the visual grades and volume was described by a quadratic model (R 2, 0.31-0.50, P < 0.01). Conclusions: ICAC volume measurement is feasible and reproducible, whereas visual grades poorly reflect the actual volume; therefore, volume measurement may be warranted for future research. Key Points: • Computed tomography provides unique information about vascular calcification. • Volume measurement of intracranial carotid artery calcification is feasible and reproducible. • Visual grades poorly reflect the volume of intracranial carotid artery calcification. • Quantification of intracranial carotid artery calcification is warranted for future research.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalEuropean Radiology
Volume23
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Internal Carotid Artery
Brain
Carotid Arteries
Vascular Calcification
Tomography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Quantification of intracranial internal carotid artery calcification on brain unenhanced CT: Evaluation of its feasibility and assessment of the reliability of visual grading scales",
abstract = "Objectives: Previous studies have evaluated intracranial internal carotid artery calcifications (ICACs) qualitatively using different visual grading scales, which could lead to inconsistent results. The purpose of this study was to evaluate the feasibility of ICAC volume measurement and to correlate the volume with visual grading scales. Methods: We included 49 patients (>50years) who underwent unenhanced cranial CT. Two observers evaluated four visual grading scales and measured ICAC volumes semi-automatically, and interobserver agreements were assessed. Differences in ICAC volume between visual grades of each scale were tested. The relationship between the visual grading and volume was assessed. Results: Interobserver agreements ranged from 0.841 to 0.901 for visual grading and 0.997 for volume measurement. Mean volumes were not significantly different between the visual grades (P > 0.05) except when comparing grade 4 with the other grades. The grades of each visual grading correlated well with ICAC volumes (Spearman's ρ = 0.849-0.881, P < 0.001). The relationship between the visual grades and volume was described by a quadratic model (R 2, 0.31-0.50, P < 0.01). Conclusions: ICAC volume measurement is feasible and reproducible, whereas visual grades poorly reflect the actual volume; therefore, volume measurement may be warranted for future research. Key Points: • Computed tomography provides unique information about vascular calcification. • Volume measurement of intracranial carotid artery calcification is feasible and reproducible. • Visual grades poorly reflect the volume of intracranial carotid artery calcification. • Quantification of intracranial carotid artery calcification is warranted for future research.",
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Quantification of intracranial internal carotid artery calcification on brain unenhanced CT : Evaluation of its feasibility and assessment of the reliability of visual grading scales. / Ahn, Sung Soo; Nam, Hyo Suk; Heo, Jihoe; Kim, Young Dae; Lee, Seung Koo; Han, Kyunghwa; Kim, Eung Yeop.

In: European Radiology, Vol. 23, No. 1, 01.01.2013, p. 20-27.

Research output: Contribution to journalArticle

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T1 - Quantification of intracranial internal carotid artery calcification on brain unenhanced CT

T2 - Evaluation of its feasibility and assessment of the reliability of visual grading scales

AU - Ahn, Sung Soo

AU - Nam, Hyo Suk

AU - Heo, Jihoe

AU - Kim, Young Dae

AU - Lee, Seung Koo

AU - Han, Kyunghwa

AU - Kim, Eung Yeop

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objectives: Previous studies have evaluated intracranial internal carotid artery calcifications (ICACs) qualitatively using different visual grading scales, which could lead to inconsistent results. The purpose of this study was to evaluate the feasibility of ICAC volume measurement and to correlate the volume with visual grading scales. Methods: We included 49 patients (>50years) who underwent unenhanced cranial CT. Two observers evaluated four visual grading scales and measured ICAC volumes semi-automatically, and interobserver agreements were assessed. Differences in ICAC volume between visual grades of each scale were tested. The relationship between the visual grading and volume was assessed. Results: Interobserver agreements ranged from 0.841 to 0.901 for visual grading and 0.997 for volume measurement. Mean volumes were not significantly different between the visual grades (P > 0.05) except when comparing grade 4 with the other grades. The grades of each visual grading correlated well with ICAC volumes (Spearman's ρ = 0.849-0.881, P < 0.001). The relationship between the visual grades and volume was described by a quadratic model (R 2, 0.31-0.50, P < 0.01). Conclusions: ICAC volume measurement is feasible and reproducible, whereas visual grades poorly reflect the actual volume; therefore, volume measurement may be warranted for future research. Key Points: • Computed tomography provides unique information about vascular calcification. • Volume measurement of intracranial carotid artery calcification is feasible and reproducible. • Visual grades poorly reflect the volume of intracranial carotid artery calcification. • Quantification of intracranial carotid artery calcification is warranted for future research.

AB - Objectives: Previous studies have evaluated intracranial internal carotid artery calcifications (ICACs) qualitatively using different visual grading scales, which could lead to inconsistent results. The purpose of this study was to evaluate the feasibility of ICAC volume measurement and to correlate the volume with visual grading scales. Methods: We included 49 patients (>50years) who underwent unenhanced cranial CT. Two observers evaluated four visual grading scales and measured ICAC volumes semi-automatically, and interobserver agreements were assessed. Differences in ICAC volume between visual grades of each scale were tested. The relationship between the visual grading and volume was assessed. Results: Interobserver agreements ranged from 0.841 to 0.901 for visual grading and 0.997 for volume measurement. Mean volumes were not significantly different between the visual grades (P > 0.05) except when comparing grade 4 with the other grades. The grades of each visual grading correlated well with ICAC volumes (Spearman's ρ = 0.849-0.881, P < 0.001). The relationship between the visual grades and volume was described by a quadratic model (R 2, 0.31-0.50, P < 0.01). Conclusions: ICAC volume measurement is feasible and reproducible, whereas visual grades poorly reflect the actual volume; therefore, volume measurement may be warranted for future research. Key Points: • Computed tomography provides unique information about vascular calcification. • Volume measurement of intracranial carotid artery calcification is feasible and reproducible. • Visual grades poorly reflect the volume of intracranial carotid artery calcification. • Quantification of intracranial carotid artery calcification is warranted for future research.

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