Quantitation of hypoechoic lesions for the prediction and Gleason grading of prostate cancer: a prospective study

Kwang Suk Lee, Kyo Chul Koo, Byung Ha Chung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Hypoechoic lesions are not included as indicators for prostate biopsy. To discriminate the features of hypoechoic lesions, we investigated the ultrasonographic characteristics of hypoechoic lesions using numerical analysis in image. In addition, we evaluated previously suggested subjective parameters on hypoechoic lesion. Methods: We performed one-core targeted biopsy (TBx) for each hypoechoic lesion in up to two lesions in each patient before the 12-core systemic biopsy was obtained between July 2015 and May 2016. Image analysis data were analyzed using grayscale values and Hounsfield units (HU) to measure heterogeneity. Subjective evaluation of hypoechoic lesions including hypoechoicity, irregularity, vascularity, and microcalcification was also validated. Results: Of 157 patients (median age = 67.1 years, median prostate-specific antigen = 6.21 ng/mL) included in the study, 77 (49.0%) were diagnosed with prostate cancer (PCa), and 39 (17.0%) diagnoses were confirmed by the results of targeted cores. The existence of hypoechoic lesions was not a final predictor for PCa detection. In multivariate analysis using a combination of clinical and quantitative image analyses, the grayscale value was identified as a significant predictive factor for the presence of PCa and high-grade disease (Gleason score ≥ 7) on target lesions. The combination of clinical and image variables had the highest area under the curve (0.890) for detecting PCa in TBx. Conclusions: The proposed method for the quantitation of hypoechoic lesions using grayscale images and HU is simple. Combined with the current clinical approaches, quantitative scoring of lesions can be useful for detecting PCa and making more precise diagnoses.

Original languageEnglish
Pages (from-to)1059-1065
Number of pages7
JournalWorld Journal of Urology
Volume36
Issue number7
DOIs
Publication statusPublished - 2018 Jul 1

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Neoplasm Grading
Prostatic Neoplasms
Prospective Studies
Biopsy
Calcinosis
Prostate-Specific Antigen
Area Under Curve
Prostate
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

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title = "Quantitation of hypoechoic lesions for the prediction and Gleason grading of prostate cancer: a prospective study",
abstract = "Purpose: Hypoechoic lesions are not included as indicators for prostate biopsy. To discriminate the features of hypoechoic lesions, we investigated the ultrasonographic characteristics of hypoechoic lesions using numerical analysis in image. In addition, we evaluated previously suggested subjective parameters on hypoechoic lesion. Methods: We performed one-core targeted biopsy (TBx) for each hypoechoic lesion in up to two lesions in each patient before the 12-core systemic biopsy was obtained between July 2015 and May 2016. Image analysis data were analyzed using grayscale values and Hounsfield units (HU) to measure heterogeneity. Subjective evaluation of hypoechoic lesions including hypoechoicity, irregularity, vascularity, and microcalcification was also validated. Results: Of 157 patients (median age = 67.1 years, median prostate-specific antigen = 6.21 ng/mL) included in the study, 77 (49.0{\%}) were diagnosed with prostate cancer (PCa), and 39 (17.0{\%}) diagnoses were confirmed by the results of targeted cores. The existence of hypoechoic lesions was not a final predictor for PCa detection. In multivariate analysis using a combination of clinical and quantitative image analyses, the grayscale value was identified as a significant predictive factor for the presence of PCa and high-grade disease (Gleason score ≥ 7) on target lesions. The combination of clinical and image variables had the highest area under the curve (0.890) for detecting PCa in TBx. Conclusions: The proposed method for the quantitation of hypoechoic lesions using grayscale images and HU is simple. Combined with the current clinical approaches, quantitative scoring of lesions can be useful for detecting PCa and making more precise diagnoses.",
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Quantitation of hypoechoic lesions for the prediction and Gleason grading of prostate cancer : a prospective study. / Lee, Kwang Suk; Koo, Kyo Chul; Chung, Byung Ha.

In: World Journal of Urology, Vol. 36, No. 7, 01.07.2018, p. 1059-1065.

Research output: Contribution to journalArticle

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