Quantitative 3D dynamic contrast-enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking

Nan Wang, Anthony G. Christodoulou, Yibin Xie, Zhenjia Wang, Zixin Deng, Bill Zhou, Sangeun Lee, Zhaoyang Fan, Hyuk-Jae Chang, Wei Yu, Debiao Li

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To develop a dynamic contrast-enhanced (DCE) MRI method capable of high spatiotemporal resolution, 3D carotid coverage, and T1-based quantification of contrast agent concentration for the assessment of carotid atherosclerosis using a newly developed Multitasking technique. Methods: 5D imaging with 3 spatial dimensions, 1 T1 recovery dimension, and 1 DCE time dimension was performed using MR Multitasking based on low-rank tensor modeling, which allows direct T1 quantification with high spatiotemporal resolution (0.7 mm isotropic and 595 ms, respectively). Saturation recovery preparations followed by 3D segmented fast low angle shot readouts were implemented with Gaussian-density random 3D Cartesian sampling. A bulk motion removal scheme was developed to improve image quality. The proposed protocol was tested in phantom and human studies. In vivo scans were performed on 14 healthy subjects and 7 patients with carotid atherosclerosis. Kinetic parameters including area under the concentration versus time curve (AUC), v p , K trans , and v e were evaluated for each case. Results: Phantom experiments showed that T1 measurements using the proposed protocol were in good agreement with reference value (R 2 = 0.96). In vivo studies demonstrated that AUC, v p , and K trans in the patient group were significantly higher than in the control group (0.63 ± 0.13 versus 0.42 ± 0.12, P < 0.001; 0.14 ± 0.05 versus 0.11 ± 0.03, P = 0.034; and 0.13 ± 0.04 versus 0.08 ± 0.02, P < 0.001, respectively). Results from repeated subjects showed good interscan reproducibility (intraclass correlation coefficient: v p , 0.83; K trans , 0.87; v e , 0.92; AUC, 0.94). Conclusion: Multitasking DCE is a promising approach for quantitatively assessing the vascularity properties of the carotid vessel wall.

Original languageEnglish
Pages (from-to)2302-2314
Number of pages13
JournalMagnetic Resonance in Medicine
Volume81
Issue number4
DOIs
Publication statusPublished - 2019 Apr 1

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Area Under Curve
Carotid Artery Diseases
Contrast Media
Healthy Volunteers
Reference Values
Control Groups

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Wang, Nan ; Christodoulou, Anthony G. ; Xie, Yibin ; Wang, Zhenjia ; Deng, Zixin ; Zhou, Bill ; Lee, Sangeun ; Fan, Zhaoyang ; Chang, Hyuk-Jae ; Yu, Wei ; Li, Debiao. / Quantitative 3D dynamic contrast-enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking. In: Magnetic Resonance in Medicine. 2019 ; Vol. 81, No. 4. pp. 2302-2314.
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title = "Quantitative 3D dynamic contrast-enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking",
abstract = "Purpose: To develop a dynamic contrast-enhanced (DCE) MRI method capable of high spatiotemporal resolution, 3D carotid coverage, and T1-based quantification of contrast agent concentration for the assessment of carotid atherosclerosis using a newly developed Multitasking technique. Methods: 5D imaging with 3 spatial dimensions, 1 T1 recovery dimension, and 1 DCE time dimension was performed using MR Multitasking based on low-rank tensor modeling, which allows direct T1 quantification with high spatiotemporal resolution (0.7 mm isotropic and 595 ms, respectively). Saturation recovery preparations followed by 3D segmented fast low angle shot readouts were implemented with Gaussian-density random 3D Cartesian sampling. A bulk motion removal scheme was developed to improve image quality. The proposed protocol was tested in phantom and human studies. In vivo scans were performed on 14 healthy subjects and 7 patients with carotid atherosclerosis. Kinetic parameters including area under the concentration versus time curve (AUC), v p , K trans , and v e were evaluated for each case. Results: Phantom experiments showed that T1 measurements using the proposed protocol were in good agreement with reference value (R 2 = 0.96). In vivo studies demonstrated that AUC, v p , and K trans in the patient group were significantly higher than in the control group (0.63 ± 0.13 versus 0.42 ± 0.12, P < 0.001; 0.14 ± 0.05 versus 0.11 ± 0.03, P = 0.034; and 0.13 ± 0.04 versus 0.08 ± 0.02, P < 0.001, respectively). Results from repeated subjects showed good interscan reproducibility (intraclass correlation coefficient: v p , 0.83; K trans , 0.87; v e , 0.92; AUC, 0.94). Conclusion: Multitasking DCE is a promising approach for quantitatively assessing the vascularity properties of the carotid vessel wall.",
author = "Nan Wang and Christodoulou, {Anthony G.} and Yibin Xie and Zhenjia Wang and Zixin Deng and Bill Zhou and Sangeun Lee and Zhaoyang Fan and Hyuk-Jae Chang and Wei Yu and Debiao Li",
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Wang, N, Christodoulou, AG, Xie, Y, Wang, Z, Deng, Z, Zhou, B, Lee, S, Fan, Z, Chang, H-J, Yu, W & Li, D 2019, 'Quantitative 3D dynamic contrast-enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking', Magnetic Resonance in Medicine, vol. 81, no. 4, pp. 2302-2314. https://doi.org/10.1002/mrm.27553

Quantitative 3D dynamic contrast-enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking. / Wang, Nan; Christodoulou, Anthony G.; Xie, Yibin; Wang, Zhenjia; Deng, Zixin; Zhou, Bill; Lee, Sangeun; Fan, Zhaoyang; Chang, Hyuk-Jae; Yu, Wei; Li, Debiao.

In: Magnetic Resonance in Medicine, Vol. 81, No. 4, 01.04.2019, p. 2302-2314.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quantitative 3D dynamic contrast-enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking

AU - Wang, Nan

AU - Christodoulou, Anthony G.

AU - Xie, Yibin

AU - Wang, Zhenjia

AU - Deng, Zixin

AU - Zhou, Bill

AU - Lee, Sangeun

AU - Fan, Zhaoyang

AU - Chang, Hyuk-Jae

AU - Yu, Wei

AU - Li, Debiao

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Purpose: To develop a dynamic contrast-enhanced (DCE) MRI method capable of high spatiotemporal resolution, 3D carotid coverage, and T1-based quantification of contrast agent concentration for the assessment of carotid atherosclerosis using a newly developed Multitasking technique. Methods: 5D imaging with 3 spatial dimensions, 1 T1 recovery dimension, and 1 DCE time dimension was performed using MR Multitasking based on low-rank tensor modeling, which allows direct T1 quantification with high spatiotemporal resolution (0.7 mm isotropic and 595 ms, respectively). Saturation recovery preparations followed by 3D segmented fast low angle shot readouts were implemented with Gaussian-density random 3D Cartesian sampling. A bulk motion removal scheme was developed to improve image quality. The proposed protocol was tested in phantom and human studies. In vivo scans were performed on 14 healthy subjects and 7 patients with carotid atherosclerosis. Kinetic parameters including area under the concentration versus time curve (AUC), v p , K trans , and v e were evaluated for each case. Results: Phantom experiments showed that T1 measurements using the proposed protocol were in good agreement with reference value (R 2 = 0.96). In vivo studies demonstrated that AUC, v p , and K trans in the patient group were significantly higher than in the control group (0.63 ± 0.13 versus 0.42 ± 0.12, P < 0.001; 0.14 ± 0.05 versus 0.11 ± 0.03, P = 0.034; and 0.13 ± 0.04 versus 0.08 ± 0.02, P < 0.001, respectively). Results from repeated subjects showed good interscan reproducibility (intraclass correlation coefficient: v p , 0.83; K trans , 0.87; v e , 0.92; AUC, 0.94). Conclusion: Multitasking DCE is a promising approach for quantitatively assessing the vascularity properties of the carotid vessel wall.

AB - Purpose: To develop a dynamic contrast-enhanced (DCE) MRI method capable of high spatiotemporal resolution, 3D carotid coverage, and T1-based quantification of contrast agent concentration for the assessment of carotid atherosclerosis using a newly developed Multitasking technique. Methods: 5D imaging with 3 spatial dimensions, 1 T1 recovery dimension, and 1 DCE time dimension was performed using MR Multitasking based on low-rank tensor modeling, which allows direct T1 quantification with high spatiotemporal resolution (0.7 mm isotropic and 595 ms, respectively). Saturation recovery preparations followed by 3D segmented fast low angle shot readouts were implemented with Gaussian-density random 3D Cartesian sampling. A bulk motion removal scheme was developed to improve image quality. The proposed protocol was tested in phantom and human studies. In vivo scans were performed on 14 healthy subjects and 7 patients with carotid atherosclerosis. Kinetic parameters including area under the concentration versus time curve (AUC), v p , K trans , and v e were evaluated for each case. Results: Phantom experiments showed that T1 measurements using the proposed protocol were in good agreement with reference value (R 2 = 0.96). In vivo studies demonstrated that AUC, v p , and K trans in the patient group were significantly higher than in the control group (0.63 ± 0.13 versus 0.42 ± 0.12, P < 0.001; 0.14 ± 0.05 versus 0.11 ± 0.03, P = 0.034; and 0.13 ± 0.04 versus 0.08 ± 0.02, P < 0.001, respectively). Results from repeated subjects showed good interscan reproducibility (intraclass correlation coefficient: v p , 0.83; K trans , 0.87; v e , 0.92; AUC, 0.94). Conclusion: Multitasking DCE is a promising approach for quantitatively assessing the vascularity properties of the carotid vessel wall.

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