Quantitative assessment of aortic elasticity with aging using velocity-vector imaging and its histologic correlation

Sung Ai Kim, Kyung Hye Lee, Ho Yeon Won, Sungha Park, Ji Hyung Chung, Yangsoo Jang, Jong Won Ha

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective-Velocity-vector imaging (VVI) represents a valuable new method for noninvasive quantification of vascular properties associated with aging. The purpose of this study was to assess the correlations between VVI parameters and histological changes with aging. Approach and Results-Fourteen mongrel dogs were classified as either young (n=7; age, 1-2 years; female; weighing 22-29 kg) or senescent (n=7; age, 8-12 years; female; weighing 36-45 kg). The short-Axis image of the descending thoracic aorta was obtained for VVI analysis with transesophageal echocardiography. The location of the image was identified using fluoroscopic guidance, and the aortic tissue was extracted. After dividing the aortic wall into 6 segments, both regional and segmental tissue collagen and elastin contents were quantified and correlated with the aortic elastic properties. In the regional analysis, the M-mode-derived aortic dimensions and elastic moduli except for intima-media thickness were not significantly different between the groups, whereas the VVI-derived aortic area and fractional area changes showed more dilated and stiffer aorta in senescent dogs. Also, fractional area change was significantly correlated with the tissue collagen content unlike the M-mode-derived elastic moduli. In the segmental analysis, the radial velocity, circumferential strain, and strain rates of VVI were more reduced in senescent dogs than young dogs, and the radial velocity and circumferential strain showed independent associations with the collagen content of the corresponding aortic wall. Conclusions-VVI was a feasible method for direct quantification of aortic elastic properties with a significant histological correlation.

Original languageEnglish
Pages (from-to)1306-1312
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume33
Issue number6
DOIs
Publication statusPublished - 2013 Jun 1

Fingerprint

Elasticity
Dogs
Collagen
Elastic Modulus
Thoracic Aorta
Elastin
Transesophageal Echocardiography
Blood Vessels
Aorta

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Quantitative assessment of aortic elasticity with aging using velocity-vector imaging and its histologic correlation",
abstract = "Objective-Velocity-vector imaging (VVI) represents a valuable new method for noninvasive quantification of vascular properties associated with aging. The purpose of this study was to assess the correlations between VVI parameters and histological changes with aging. Approach and Results-Fourteen mongrel dogs were classified as either young (n=7; age, 1-2 years; female; weighing 22-29 kg) or senescent (n=7; age, 8-12 years; female; weighing 36-45 kg). The short-Axis image of the descending thoracic aorta was obtained for VVI analysis with transesophageal echocardiography. The location of the image was identified using fluoroscopic guidance, and the aortic tissue was extracted. After dividing the aortic wall into 6 segments, both regional and segmental tissue collagen and elastin contents were quantified and correlated with the aortic elastic properties. In the regional analysis, the M-mode-derived aortic dimensions and elastic moduli except for intima-media thickness were not significantly different between the groups, whereas the VVI-derived aortic area and fractional area changes showed more dilated and stiffer aorta in senescent dogs. Also, fractional area change was significantly correlated with the tissue collagen content unlike the M-mode-derived elastic moduli. In the segmental analysis, the radial velocity, circumferential strain, and strain rates of VVI were more reduced in senescent dogs than young dogs, and the radial velocity and circumferential strain showed independent associations with the collagen content of the corresponding aortic wall. Conclusions-VVI was a feasible method for direct quantification of aortic elastic properties with a significant histological correlation.",
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Quantitative assessment of aortic elasticity with aging using velocity-vector imaging and its histologic correlation. / Kim, Sung Ai; Lee, Kyung Hye; Won, Ho Yeon; Park, Sungha; Chung, Ji Hyung; Jang, Yangsoo; Ha, Jong Won.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 33, No. 6, 01.06.2013, p. 1306-1312.

Research output: Contribution to journalArticle

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T1 - Quantitative assessment of aortic elasticity with aging using velocity-vector imaging and its histologic correlation

AU - Kim, Sung Ai

AU - Lee, Kyung Hye

AU - Won, Ho Yeon

AU - Park, Sungha

AU - Chung, Ji Hyung

AU - Jang, Yangsoo

AU - Ha, Jong Won

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JO - Arteriosclerosis, Thrombosis, and Vascular Biology

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