Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children

A pilot feasibility study

Hyun Gi Kim, Hyun Joo Shin, Yoon Hee Kim, Myung Hyun Sohn, Chuhl Joo Lyu, Myung Joon Kim, Kyung Won Kim, MiJung Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). Methods: This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. Results: The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 % and 1.4 ± 1.9 %, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). Conclusions: We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. Key Points: • Simple and individualized threshold attenuation setting for air trapping quantification is possible. • Individualized threshold attenuation setting is insusceptible to CT imaging protocols or respiratory phase control. • CT air trapping quantification correlates with PFT of pulmonary obstruction.

Original languageEnglish
Pages (from-to)2931-2936
Number of pages6
JournalEuropean Radiology
Volume25
Issue number10
DOIs
Publication statusPublished - 2015 Oct 13

Fingerprint

Bronchiolitis Obliterans
Feasibility Studies
Graft vs Host Disease
Air
Tomography
Respiratory Function Tests
Lung
Research Ethics Committees
Linear Models
Thorax
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Hyun Gi ; Shin, Hyun Joo ; Kim, Yoon Hee ; Sohn, Myung Hyun ; Lyu, Chuhl Joo ; Kim, Myung Joon ; Kim, Kyung Won ; Lee, MiJung. / Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children : A pilot feasibility study. In: European Radiology. 2015 ; Vol. 25, No. 10. pp. 2931-2936.
@article{044cb634b0fa4d29a60643ed3ae3c109,
title = "Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children: A pilot feasibility study",
abstract = "Objective: To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). Methods: This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. Results: The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 {\%} and 1.4 ± 1.9 {\%}, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC{\%} in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). Conclusions: We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. Key Points: • Simple and individualized threshold attenuation setting for air trapping quantification is possible. • Individualized threshold attenuation setting is insusceptible to CT imaging protocols or respiratory phase control. • CT air trapping quantification correlates with PFT of pulmonary obstruction.",
author = "Kim, {Hyun Gi} and Shin, {Hyun Joo} and Kim, {Yoon Hee} and Sohn, {Myung Hyun} and Lyu, {Chuhl Joo} and Kim, {Myung Joon} and Kim, {Kyung Won} and MiJung Lee",
year = "2015",
month = "10",
day = "13",
doi = "10.1007/s00330-015-3700-9",
language = "English",
volume = "25",
pages = "2931--2936",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "10",

}

Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children : A pilot feasibility study. / Kim, Hyun Gi; Shin, Hyun Joo; Kim, Yoon Hee; Sohn, Myung Hyun; Lyu, Chuhl Joo; Kim, Myung Joon; Kim, Kyung Won; Lee, MiJung.

In: European Radiology, Vol. 25, No. 10, 13.10.2015, p. 2931-2936.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children

T2 - A pilot feasibility study

AU - Kim, Hyun Gi

AU - Shin, Hyun Joo

AU - Kim, Yoon Hee

AU - Sohn, Myung Hyun

AU - Lyu, Chuhl Joo

AU - Kim, Myung Joon

AU - Kim, Kyung Won

AU - Lee, MiJung

PY - 2015/10/13

Y1 - 2015/10/13

N2 - Objective: To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). Methods: This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. Results: The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 % and 1.4 ± 1.9 %, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). Conclusions: We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. Key Points: • Simple and individualized threshold attenuation setting for air trapping quantification is possible. • Individualized threshold attenuation setting is insusceptible to CT imaging protocols or respiratory phase control. • CT air trapping quantification correlates with PFT of pulmonary obstruction.

AB - Objective: To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). Methods: This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. Results: The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 % and 1.4 ± 1.9 %, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). Conclusions: We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. Key Points: • Simple and individualized threshold attenuation setting for air trapping quantification is possible. • Individualized threshold attenuation setting is insusceptible to CT imaging protocols or respiratory phase control. • CT air trapping quantification correlates with PFT of pulmonary obstruction.

UR - http://www.scopus.com/inward/record.url?scp=84941417244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941417244&partnerID=8YFLogxK

U2 - 10.1007/s00330-015-3700-9

DO - 10.1007/s00330-015-3700-9

M3 - Article

VL - 25

SP - 2931

EP - 2936

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 10

ER -