Quantitative evaluation of vascularity using 2-D power doppler ultrasonography may not identify malignancy of the thyroid

Jung Hyun Yoon, Hyun Joo Shin, Eunkyung Kim, Hee Jung Moon, Yun Ho Roh, jinyoung kwak

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4 Citations (Scopus)


The purpose of this study was to evaluate the usefulness of a quantitative vascular index in predicting thyroid malignancy. A total of 1309 thyroid nodules in 1257 patients (mean age: 50.2 y, range: 18-83 y) were included. The vascularity pattern and vascular index (VI) measured by quantification software for each nodule were obtained from 2-D power Doppler ultrasonography (US). Gray-scale US + vascularity pattern was compared with gray-scale US + VI with respect to diagnostic performance. Of the 1309 thyroid nodules, 927 (70.8%) were benign and 382 (29.2%) were malignant. The area under the receiver operating characteristics curve (Az) for gray-scale US (0.82) was significantly higher than that for US combined with vascularity pattern (0.77) or VI (0.70, all p < 0.001). Quantified VIs were higher in benign nodules, but did not improve the performance of 2-D US in diagnosing thyroid malignancy.

Original languageEnglish
Pages (from-to)2873-2883
Number of pages11
JournalUltrasound in Medicine and Biology
Issue number11
Publication statusPublished - 2015 Nov 1


All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

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