Quantitative proteomic analysis of the expression of SARS-CoV-2 receptors in the gut of patients with chronic enterocolitis

Jihye Park, Daeun Jeong, Youn Wook Chung, Da Hye Kim, Jae Hee Cheon, Ji Hwan Ryu

Research output: Contribution to journalArticlepeer-review

Abstract

The cellular entry of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is mediated by interaction with the human angio-tensin-converting enzyme 2 (ACE2), a receptor that is expressed on both lung and intestinal epithelial cells. We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn’s disease (CD), intestinal Behćet’s disease (BD), and intestinal tuberculosis (TB), when compared with that of healthy indi-viduals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopepti-dase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD, and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.

Original languageEnglish
Pages (from-to)891-894
Number of pages4
JournalYonsei medical journal
Volume61
Issue number10
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT & Future Planning (grant number 2017M3A9F3041229), and a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health & Welfare, Republic of Korea (grant number HI18C0094).

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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