Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences

Jung Hoon Lee, Yong Beom Lim, Joon Sig Choi, Myung Un Choi, Chul Hak Yang, Jong Sang Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Quaternary ammonium groups were introduced to Starburst polyamidoamine (PAMAM) dendrimers for a gene carrier. These quaternary dendritic carriers exhibited reduced cytotoxicity on 293T cells compared to parent dendrimers examined and their transfection efficiency were similar with parent dendrimers. Quaternization could be a promising tool to improve properties of dendrimers as a gene delivery carrier.

Original languageEnglish
Pages (from-to)1637-1640
Number of pages4
JournalBulletin of the Korean Chemical Society
Volume24
Issue number11
DOIs
Publication statusPublished - 2003 Nov 20

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Dendrimers
Genes
Cytotoxicity
Ammonium Compounds
Poly(amidoamine)

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Lee, Jung Hoon ; Lim, Yong Beom ; Choi, Joon Sig ; Choi, Myung Un ; Yang, Chul Hak ; Park, Jong Sang. / Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System : Relationship between Degree of Quaternization and Their Influences. In: Bulletin of the Korean Chemical Society. 2003 ; Vol. 24, No. 11. pp. 1637-1640.
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Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System : Relationship between Degree of Quaternization and Their Influences. / Lee, Jung Hoon; Lim, Yong Beom; Choi, Joon Sig; Choi, Myung Un; Yang, Chul Hak; Park, Jong Sang.

In: Bulletin of the Korean Chemical Society, Vol. 24, No. 11, 20.11.2003, p. 1637-1640.

Research output: Contribution to journalArticle

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