Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences

Jung Hoon Lee, Yong Beom Lim, Joon Sig Choi, Myung Un Choi, Chul Hak Yang, Jong Sang Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Quaternary ammonium groups were introduced to Starburst polyamidoamine (PAMAM) dendrimers for a gene carrier. These quaternary dendritic carriers exhibited reduced cytotoxicity on 293T cells compared to parent dendrimers examined and their transfection efficiency were similar with parent dendrimers. Quaternization could be a promising tool to improve properties of dendrimers as a gene delivery carrier.

Original languageEnglish
Pages (from-to)1637-1640
Number of pages4
JournalBulletin of the Korean Chemical Society
Volume24
Issue number11
DOIs
Publication statusPublished - 2003 Nov 20

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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