QUIRKY regulates root epidermal cell patterning through stabilizing SCRAMBLED to control CAPRICE movement in Arabidopsis

Jae Hyo Song, Su Hwan Kwak, Kyoung Hee Nam, John Schiefelbein, Myeong Min Lee

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

SCM, a leucine-rich repeat receptor-like kinase, is required for root epidermal cells to appropriately interpret their location and generate the proper cell-type pattern during Arabidopsis root development. Here, via a screen for scm-like mutants we describe a new allele of the QKY gene. We find that QKY is required for the appropriate spatial expression of several epidermal cell fate regulators in a similar manner as SCM in roots, and that QKY and SCM are necessary for the efficient movement of CPC between epidermal cells. We also show that turnover of SCM is mediated by a vacuolar degradation pathway triggered by ubiquitination, and that QKY prevents this SCM ubiquitination through their physical interaction. These results suggest that QKY stabilizes SCM through interaction, and this complex facilitates CPC movement between the epidermal cells to help establish the cell-type pattern in the Arabidopsis root epidermis.

Original languageEnglish
Article number1744
JournalNature communications
Volume10
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

Bibliographical note

Funding Information:
This work was supported by a grant from Woo Jang Choon Project (grant number, PJ01093905 to M.M.L.) of the Rural Development Administration (RDA), Republic of Korea, and by a grant from the Basic Science Research Program through the National Research Foundation (NRF) (grant number 2018R1A6A1A03025607) funded by the Ministry of Education, Republic of Korea.

Publisher Copyright:
© 2019, The Author(s).

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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