Radiation-induced lung fibrosis: Preclinical animal models and therapeutic strategies

Hee Jin, Youngjo Yoo, Younghwa Kim, Yeijin Kim, Jaeho Cho, Yun Sil Lee

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)


Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic radiation-induced lung fibrosis, is the most common side effect of radiation therapy. RILI is a complicated process that causes the accumulation, proliferation, and differentiation of fibroblasts and, finally, results in excessive extracellular matrix deposition. Currently, there are no approved treatment options for patients with radiation-induced pulmonary fibrosis (RIPF) partly due to the absence of effective targets. Current research advances include the development of small animal models reflecting modern radiotherapy, an understanding of the molecular basis of RIPF, and the identification of candidate drugs for prevention and treatment. Insights provided by this research have resulted in increased interest in disease progression and prognosis, the development of novel anti-fibrotic agents, and a more targeted approach to the treatment of RIPF.

Original languageEnglish
Article number1561
Pages (from-to)1-24
Number of pages24
Issue number6
Publication statusPublished - 2020 Jun

Bibliographical note

Funding Information:
This work was supported by a grant from the National Research Foundation of Korea (NRF) grants (NRF-2018R1A5A2025286, 2019R1A2C2086448 and 2020R1A2C3013255), funded by the Korean government (Ministry of Science and ICT).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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