An efficient and mild method is developed for radical deoxygenation of alcohols and formation of carbon-carbon bonds in water without adding additives such as surfactants. The reaction was applied to synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides that are potent anti-HIV agents. The reaction afforded environmentally benign reaction conditions.
Bibliographical noteFunding Information:
This work was supported by Korea Research Foundation Grant (KRF-2003-002-C00155).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry