Radical-mediated intramolecular C-C bond formation and the deoxygenation of alcohols under solvent-free conditions with tributyl methyl ammonium hypophosphite

Eun Hwa Lee, Dae Hyan Cho, Apuri Satyender, Doo Ok Jang

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A green, solvent-free protocol was developed for the radical-mediated intramolecular cyclization of haloacetals and the deoxygenation of S-methyl dithiocarbonates and cyclic thionocarbonate. This process uses tributyl methyl ammonium hypophosphite as a H-donor in the presence of triethylborane or t-butyl peroxide. This methodology provides eco-friendly reaction conditions.

Original languageEnglish
Pages (from-to)6927-6929
Number of pages3
JournalTetrahedron Letters
Issue number51
Publication statusPublished - 2011 Dec 21


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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