Radical-mediated intramolecular C-C bond formation and the deoxygenation of alcohols under solvent-free conditions with tributyl methyl ammonium hypophosphite

Eun Hwa Lee; Dae Hyan Cho; Apuri Satyender; Doo Ok Jang

doi:10.1016/j.tetlet.2011.10.063

Radical-mediated intramolecular C-C bond formation and the deoxygenation of alcohols under solvent-free conditions with tributyl methyl ammonium hypophosphite

Eun Hwa Lee, Dae Hyan Cho, Apuri Satyender, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A green, solvent-free protocol was developed for the radical-mediated intramolecular cyclization of haloacetals and the deoxygenation of S-methyl dithiocarbonates and cyclic thionocarbonate. This process uses tributyl methyl ammonium hypophosphite as a H-donor in the presence of triethylborane or t-butyl peroxide. This methodology provides eco-friendly reaction conditions.

Original language	English
Pages (from-to)	6927-6929
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	51
DOIs	https://doi.org/10.1016/j.tetlet.2011.10.063
Publication status	Published - 2011 Dec 21

Bibliographical note

Funding Information:
This work was supported by the Center for Bioactive Molecular Hybrids .

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2011.10.063

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abstract = "A green, solvent-free protocol was developed for the radical-mediated intramolecular cyclization of haloacetals and the deoxygenation of S-methyl dithiocarbonates and cyclic thionocarbonate. This process uses tributyl methyl ammonium hypophosphite as a H-donor in the presence of triethylborane or t-butyl peroxide. This methodology provides eco-friendly reaction conditions.",

author = "Lee, {Eun Hwa} and Cho, {Dae Hyan} and Apuri Satyender and Jang, {Doo Ok}",

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AU - Lee, Eun Hwa

AU - Cho, Dae Hyan

AU - Satyender, Apuri

AU - Jang, Doo Ok

N1 - Funding Information: This work was supported by the Center for Bioactive Molecular Hybrids .

PY - 2011/12/21

Y1 - 2011/12/21

N2 - A green, solvent-free protocol was developed for the radical-mediated intramolecular cyclization of haloacetals and the deoxygenation of S-methyl dithiocarbonates and cyclic thionocarbonate. This process uses tributyl methyl ammonium hypophosphite as a H-donor in the presence of triethylborane or t-butyl peroxide. This methodology provides eco-friendly reaction conditions.

AB - A green, solvent-free protocol was developed for the radical-mediated intramolecular cyclization of haloacetals and the deoxygenation of S-methyl dithiocarbonates and cyclic thionocarbonate. This process uses tributyl methyl ammonium hypophosphite as a H-donor in the presence of triethylborane or t-butyl peroxide. This methodology provides eco-friendly reaction conditions.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 51

ER -

Radical-mediated intramolecular C-C bond formation and the deoxygenation of alcohols under solvent-free conditions with tributyl methyl ammonium hypophosphite

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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