Abstract
A radical "on water" addition to the C=N bond of hydrazones has been described. Hydrazone, diphenylsilane, alkyl iodide, and triethylborane afforded the corresponding addition products "on water" in good yields. A significant solvent effect was observed from the water. The developed protocol can be applied to the synthesis of 3-substituted isoindolinone derivatives. Moreover, the process offers environmentally benign tin-free radical reaction conditions.
Original language | English |
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Pages (from-to) | 7373-7379 |
Number of pages | 7 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2018 Jul 20 |
Bibliographical note
Funding Information:This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A3B03932348).
Publisher Copyright:
© 2018 American Chemical Society.
All Science Journal Classification (ASJC) codes
- Organic Chemistry