Radiofrequency Ablation of Atrial Fibrillation Raises Plasma Levels of Nerve Growth Factor-beta, and Is Associated with Post-Ablation Premature Ventricular Contractions

Jin Wi, Jung Min Kim, Boyoung Joung, Moon Hyoung Lee, huinam pak

Research output: Contribution to journalArticle

Abstract

Introduction: Nerve growth factor-ß (NGF-ß) expression is increased after radiofrequency ablation (RFA) in patients with atrial fibrillation (AF), indicating cardiac nerve sprouting. We investigated relationship between NGF-ß levles before and after RFA and variables in Holter monitoring after RFA in AF patients. Methods: This study included 307 AF patients (236 men, 55.7±11.1 years, 209 paroxysmal AF) underwent RFA. Plasma levels of NGF-ß were quantified before and after RFA and Holter monitoring was performed 3 months after RFA. Continuous variables were assessed using the median value as cut-off points. Results: NGF-ß levels increased after RFA, compared to before RFA (20.98±14.24 vs. 29.57±19.47 pg/mL, p<0.001). Patients with pre-RFA NGF-ß>17.20 pg/mL had higher proportions of premature ventricular contractions (PVCs) (0.06±0.36 vs. 0.01±0.09%, p=0.038) and LF/HF ratio (1.36±0.52 vs. 1.22± 0.41, p=0.007) in Holter monitoring than those with ‘T17.20 pg/mL. In patients without increase of NGF-ß after RFA, left atrial (LA) was larger (68.3±20.2 vs. 56.9±19.0 mL, p=0.010), and LA appendage voltage (1.97±1.05 vs. 2.53± 1.50 mV, p=0.028) and LF/HF ratio (1.15±0.40 vs. 1.32±0.48, p=0.020) were lower, compared to those with increase of NGF-ß. Conclusion: Higher pre-RFA NGF-ß levels were related to high frequency of PVCs and LF/HF ratio in Holter monitoring after RFA. Lower NGF-ß levels were related with electroanatomical remodeling of LA, including larger LA and lower LA voltage.

Original languageEnglish
Number of pages1
Journaljournal of arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1

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Ventricular Premature Complexes
Nerve Growth Factor
Atrial Fibrillation
Ambulatory Electrocardiography
Atrial Remodeling
Atrial Appendage

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{1aefdf557367442c88d5976709c32fd4,
title = "Radiofrequency Ablation of Atrial Fibrillation Raises Plasma Levels of Nerve Growth Factor-beta, and Is Associated with Post-Ablation Premature Ventricular Contractions",
abstract = "Introduction: Nerve growth factor-{\ss} (NGF-{\ss}) expression is increased after radiofrequency ablation (RFA) in patients with atrial fibrillation (AF), indicating cardiac nerve sprouting. We investigated relationship between NGF-{\ss} levles before and after RFA and variables in Holter monitoring after RFA in AF patients. Methods: This study included 307 AF patients (236 men, 55.7±11.1 years, 209 paroxysmal AF) underwent RFA. Plasma levels of NGF-{\ss} were quantified before and after RFA and Holter monitoring was performed 3 months after RFA. Continuous variables were assessed using the median value as cut-off points. Results: NGF-{\ss} levels increased after RFA, compared to before RFA (20.98±14.24 vs. 29.57±19.47 pg/mL, p<0.001). Patients with pre-RFA NGF-{\ss}>17.20 pg/mL had higher proportions of premature ventricular contractions (PVCs) (0.06±0.36 vs. 0.01±0.09{\%}, p=0.038) and LF/HF ratio (1.36±0.52 vs. 1.22± 0.41, p=0.007) in Holter monitoring than those with ‘T17.20 pg/mL. In patients without increase of NGF-{\ss} after RFA, left atrial (LA) was larger (68.3±20.2 vs. 56.9±19.0 mL, p=0.010), and LA appendage voltage (1.97±1.05 vs. 2.53± 1.50 mV, p=0.028) and LF/HF ratio (1.15±0.40 vs. 1.32±0.48, p=0.020) were lower, compared to those with increase of NGF-{\ss}. Conclusion: Higher pre-RFA NGF-{\ss} levels were related to high frequency of PVCs and LF/HF ratio in Holter monitoring after RFA. Lower NGF-{\ss} levels were related with electroanatomical remodeling of LA, including larger LA and lower LA voltage.",
author = "Jin Wi and Kim, {Jung Min} and Boyoung Joung and Lee, {Moon Hyoung} and huinam pak",
year = "2011",
month = "1",
day = "1",
doi = "10.4020/jhrs.27.OP20_5",
language = "English",
volume = "27",
journal = "Journal of Arrhythmia",
issn = "1880-4276",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Radiofrequency Ablation of Atrial Fibrillation Raises Plasma Levels of Nerve Growth Factor-beta, and Is Associated with Post-Ablation Premature Ventricular Contractions

AU - Wi, Jin

AU - Kim, Jung Min

AU - Joung, Boyoung

AU - Lee, Moon Hyoung

AU - pak, huinam

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Introduction: Nerve growth factor-ß (NGF-ß) expression is increased after radiofrequency ablation (RFA) in patients with atrial fibrillation (AF), indicating cardiac nerve sprouting. We investigated relationship between NGF-ß levles before and after RFA and variables in Holter monitoring after RFA in AF patients. Methods: This study included 307 AF patients (236 men, 55.7±11.1 years, 209 paroxysmal AF) underwent RFA. Plasma levels of NGF-ß were quantified before and after RFA and Holter monitoring was performed 3 months after RFA. Continuous variables were assessed using the median value as cut-off points. Results: NGF-ß levels increased after RFA, compared to before RFA (20.98±14.24 vs. 29.57±19.47 pg/mL, p<0.001). Patients with pre-RFA NGF-ß>17.20 pg/mL had higher proportions of premature ventricular contractions (PVCs) (0.06±0.36 vs. 0.01±0.09%, p=0.038) and LF/HF ratio (1.36±0.52 vs. 1.22± 0.41, p=0.007) in Holter monitoring than those with ‘T17.20 pg/mL. In patients without increase of NGF-ß after RFA, left atrial (LA) was larger (68.3±20.2 vs. 56.9±19.0 mL, p=0.010), and LA appendage voltage (1.97±1.05 vs. 2.53± 1.50 mV, p=0.028) and LF/HF ratio (1.15±0.40 vs. 1.32±0.48, p=0.020) were lower, compared to those with increase of NGF-ß. Conclusion: Higher pre-RFA NGF-ß levels were related to high frequency of PVCs and LF/HF ratio in Holter monitoring after RFA. Lower NGF-ß levels were related with electroanatomical remodeling of LA, including larger LA and lower LA voltage.

AB - Introduction: Nerve growth factor-ß (NGF-ß) expression is increased after radiofrequency ablation (RFA) in patients with atrial fibrillation (AF), indicating cardiac nerve sprouting. We investigated relationship between NGF-ß levles before and after RFA and variables in Holter monitoring after RFA in AF patients. Methods: This study included 307 AF patients (236 men, 55.7±11.1 years, 209 paroxysmal AF) underwent RFA. Plasma levels of NGF-ß were quantified before and after RFA and Holter monitoring was performed 3 months after RFA. Continuous variables were assessed using the median value as cut-off points. Results: NGF-ß levels increased after RFA, compared to before RFA (20.98±14.24 vs. 29.57±19.47 pg/mL, p<0.001). Patients with pre-RFA NGF-ß>17.20 pg/mL had higher proportions of premature ventricular contractions (PVCs) (0.06±0.36 vs. 0.01±0.09%, p=0.038) and LF/HF ratio (1.36±0.52 vs. 1.22± 0.41, p=0.007) in Holter monitoring than those with ‘T17.20 pg/mL. In patients without increase of NGF-ß after RFA, left atrial (LA) was larger (68.3±20.2 vs. 56.9±19.0 mL, p=0.010), and LA appendage voltage (1.97±1.05 vs. 2.53± 1.50 mV, p=0.028) and LF/HF ratio (1.15±0.40 vs. 1.32±0.48, p=0.020) were lower, compared to those with increase of NGF-ß. Conclusion: Higher pre-RFA NGF-ß levels were related to high frequency of PVCs and LF/HF ratio in Holter monitoring after RFA. Lower NGF-ß levels were related with electroanatomical remodeling of LA, including larger LA and lower LA voltage.

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