Radiological and histopathological analyses of two bile duct adenoma cases focused on washout in the portal phase of contrast-enhanced ultrasound

Soo Ki Kim, Takako Fujii, Soo Ryang Kim, Hisato Kobayashi, Toyokazu Okuda, Takanobu Hayakumo, Yumi Fujii, Atsushi Nakai, Aya Ohtani, Ke Ih Kim, Osamu Nakashima, Tsutomu Kumabe, Motoko Sasaki, Yu Ichiro Koma, Soichi Kubo, Hiroshi Yasui, Takakazu Matsushita, Hironori Tanaka, Akira Yamada

Research output: Contribution to journalArticlepeer-review

Abstract

Ultrasound (US) revealed a 6-mm hypoechoic nodule in segment 6 of a 65-year-old man with alcoholic cirrhosis (Case 1) and a 7-mm hypoechoic nodule in segment 5 of a 70-year-old man with chronic hepatitis C (Case 2). Contrast-enhanced US (CEUS), CE computed tomogra-phy, and CE magnetic resonance imaging of the nodules in both cases revealed hypervascularity in the early phase and washout in the late phase. CEUS with the use of perflubutane revealed washout in the portal phase, which differentiates these nodules from hepato-cellular carcinoma. Histopathologically, the nodules showed proliferation of small 30-μm bile ducts with slight atypia. Immunohistochemically, these were posi-tive for p16INK4a and Ki67 index (0%-3%) and negative for EZH 2, distinguishing them from cholangiolocellular carcinoma.

Original languageEnglish
Pages (from-to)765-769
Number of pages5
JournalActa Hepatologica Japonica
Volume62
Issue number11
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 The Japan Society of Hepatology.

All Science Journal Classification (ASJC) codes

  • Hepatology

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