Radiomics MRI phenotyping with machine learning to predict the grade of lower-grade gliomas: A study focused on nonenhancing tumors

Yae Won Park, Yoon Seong Choi, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung Koo Lee

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Objective: To assess whether radiomics features derived from multiparametric MRI can predict the tumor grade of lower-grade gliomas (LGGs; World Health Organization grade II and grade III) and the nonenhancing LGG subgroup. Materials and Methods: Two-hundred four patients with LGGs from our institutional cohort were allocated to training (n = 136) and test (n = 68) sets. Postcontrast T1-weighted images, T2-weighted images, and fluid-attenuated inversion recovery images were analyzed to extract 250 radiomics features. Various machine learning classifiers were trained using the radiomics features to predict the glioma grade. The trained classifiers were internally validated on the institutional test set and externally validated on a separate cohort (n = 99) from The Cancer Genome Atlas (TCGA). Classifier performance was assessed by determining the area under the curve (AUC) from receiver operating characteristic curve analysis. An identical process was performed in the nonenhancing LGG subgroup (institutional training set, n = 73; institutional test set, n = 37; and TCGA cohort, n = 37) to predict the glioma grade. Results: The performance of the best classifier was good in the internal validation set (AUC, 0.85) and fair in the external validation set (AUC, 0.72) to predict the LGG grade. For the nonenhancing LGG subgroup, the performance of the best classifier was good in the internal validation set (AUC, 0.82), but poor in the external validation set (AUC, 0.68). Conclusion: Radiomics feature-based classifiers may be useful to predict LGG grades. However, radiomics classifiers may have a limited value when applied to the nonenhancing LGG subgroup in a TCGA cohort.

Original languageEnglish
Pages (from-to)1381-1389
Number of pages9
JournalKorean journal of radiology
Volume20
Issue number9
DOIs
Publication statusPublished - 2019 Sep

Bibliographical note

Funding Information:
Received November 26, 2018; accepted after revision April 21, 2019. This study was supported by a faculty research grant of Yonsei University College of Medicine (6-2016-0121). Corresponding author: Yoon Seong Choi, MD, PhD, Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea. • Tel: (822) 2228-7400 • Fax: (822) 393-3035 • E-mail: yoonseong.choi07@gmail.com This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:// creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher Copyright:
© 2019 The Korean Society of Radiology.

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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